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《ACTA PHARMACEUTICA SINICA》 1999-03
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METABOLISM OF ORALLY ADMINISTERED ICARIIN IN RATS

Qiu Feng (Qiu F), Chen Yingjie (Chen YJ), Kano Yoshihiro (Kano YH) 1 and Yao Xinsheng (Yao XS) (Shenyang Pharmaceutical University, Shenyang 110015; 1Hokkaido College of Pharmacy, Katsuraoka 7 1, Otaru 047 02, Japan)  
AIM: To evaluate the pharmacological action of icariin in traditional Chinese medicines. METHODS: Icariin was given orally to rats, the major metabolites of icariin in gastric, small intestinal, urine and bile samples were determined and isolated by HPLC and identified by chemical and spectroscopic evidences. RESULTS: Two metabolites, icariside II and icaritin in both small intestine and urine, and two metabolites, icaritin 3 O α L rhamnopyranosyl 7 O β D glucopyranuronoside and icariside II in bile were identified. The major metabolic route of orally administered icariin in rats was also proposed. CONCLUSION: Icariin is metabolized prior to absorption and exists mainly as its metabolites in vivo .
【Key Words】： icariin icariside II icaritin icaritin 3 O α L rhammopyranosyl 7 O β D glucopyranuronoside metabolite
【Fund】： 辽宁省科学技术基金
【CateGory Index】： R285.5
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【References】
Chinese Journal Full-text Database 9 Hits
1 DOU Jian-Peng, LIU Zhi-Qiang *, LIU Shu-Ying *(Laboratory of New Drug Research, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China);Studies on Icariin by Electrospray Ionization Mass Spectrometry[J];Chemical Research In Chinese Universities;2004-05
2 Peng Wenda Hunan Mawangdui nursing homes,Changsha 410001;Yigan icariin Epimedium particles and pharmacokinetic study in rats[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2010-06
3 Wang Qiao, Liu Rongxia and Guo Dean ( Modern ResearchCenter of Traditional Chinese Medicine, Peking University, Beijing 100083 ) Bi Kaishun ( Shengyang University of Materia medica , Shengyang 110016, Liaoning Province of China );Present Situation and Prospects of Studies on Metabolism of Traditional Chinese Medicine[J];;2003-06
4 Song Jiannan (Institute of Basic Theory,China Academy of Traditional Chinese Medicine,Beijing 100700,China);The wholism of Traditional Chinese Medicine and the whole effective moleculeome of Chinese traditional herbs[J];;2006-03
5 Xu Wen~1 Zhang Yaping~1 Zhang Weidong~(1,2*) Zhang Xinmin~3 Shen Ziyi~3 1.School of Pharmacy, Second Military Medical University, Shanghai 200433; 2.School of Pharmacy, Shanghai Jiao Tong University, Shanghai 201203; 3.Huashan Hospital of Fudan University, Shanghai 200040;Metabolism of Icariin and Icariside Ⅱ by Rat Intestinal Bacteria In Vitro[J];;2006-06
6 Liu Tiehan, Wang Benxiang, Wang Yi, Guo Yingjie, Wu Lijun 1, Mutsuhiko Minami 2, Toshi Nagata 3 and Takashi Ikejima 3 (New Drug Research Center, Changchun College of Traditional Chinese Medicine, Changchun 130021; 1Research Department o;EFFECT OF ICARIIN AND ITS METABOLITES ON THE PRODUCTION OF CYTOKINES BY THP-1 CELLS[J];ACTA PHARMACEUTICA SINICA;2000-04
7 School of Pharmacy, West China University of Medical Sciences (Chengdu 610041) Yang Changming, Hou Shixiang and Zhang Zhirong;Recent Advances in Metabolic Chemistry of Traditional Chinese Drugs[J];CHINESE TRADITIONAL AND HERBAL DRUGS;2000-09
8 MA Hui-ping1,JIA Zheng-ping1,CHENG Ke-ming2,ZHANG Ru-xue1,LI Mao-xing,WANG Juan1(1.Department of Pharmacy,Lanzhou General Hospital,PLA,Lanzhou 730050,China;2.Imstitute of Orthopaedics,Lanzhou General Hospital,PLA,Lanzhou 730050,China);Effects of rat serum containing total flavonoid extract of Epimedium sagittatum on development of osteoblasts[J];China Journal of Chinese Materia Medica;2008-08
9 SONG Xiao-li and QIAN Rui-qin Department of Integrated Traditional Chinese and Western Medicine,School of Basic Medical Sciences,Peking University,Beijing(100083);Progress of Researches on Pharmacokinetics of Active Components of Chinese Drugs[J];Chinese Journal of Integrated Traditional and Western Medicine;2008-10
China Proceedings of conference Full-text Database 1 Hits
1 DOU Jian-peng, LIU Zhi-qiang, LIU Shu-ying(Laboratory of New Drug Research, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China);Studies on Flavonoids Extracted From Epimedii Herba by Electrospray Ionization Multi-stage Tandem Mass Spectrometry[A];[C];2003
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Zhao Yong;Zhang Ling;Cui Zhengyan;et al(Institute of Basic,Shandong Provincial Academy of Medical Sciences,Jina);Studies on the Immuno Modulatory Action of Icarrin[J];Chinese Traditional and Herbal Drugs;1996-11
2 GuoBaolinandXiaoPeigen(InstituteofMedicinalPlant,ChineseAcademyofMedicalSciencesandPekingUnionMedicalColege100094);DeterminationofFlavonoidsinDifferentPartsofFiveEpimediumPlants[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1996-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Ou Zenan, et al ( Department of Chinese Traditional Medicine, Laboratory of CTM and WM );Immuno-pharmacological studies of Guan Jie Ling——III. Inhibition effect of Guan Jie Ling oncellular immunity and its reversion[J];Journal of First Military Medical University;1987-01
2 Li Li~1,2 , Dou Jianpeng1, Wu Wei1, Liu Zhiqiang~*1 , Liu Shuying1 ~ 1(Laboratory of New Drug Research, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) ~ 2(Graduate School of the Chinese Academy of Sciences, Beijing 100039);Study on Flavonoids in Plant Extracts from Epimedium Koreanum Nakai. by Liquid Chromatography-Electrospray Ionization Mass Spectrometry[J];Chinese Journal of Analytical Chemistry;2005-03
3 MENG Ning,KONG Kai,LI Shi-weng(School of Chemical and Biological Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China);Advances in Studies on Chemical Constituents and Pharmaceutical Activities in Species of Epimedium[J];Acta Botanica Boreali-Occidentalia Sinica;2010-05
4 HOU Ji-rui~1, SHENG Ji-min~2, WANG Xiu-quan~1, TIAN Yi-xin~1,　WU Gou-ju~1 (1. College of Chinese Medicinal Material, Jilin Agricultural University, Changchun, Jilin 130118, China; 2. Forestry Bureau of Changbai County, Changbai, Jilin 134400, China );Advances in Studies on Herba epimedii[J];Journal of Jilin Agricultural University;2004-01
5 SHI Jing-xiao,LI Hu-min,LIU Ying-di,CHEN Jun (College of Life Sciences and Chemistry,Jishou University,Jishou 416000,Hunan China);Advance in Research of Epimedium L. Ecophysiology[J];JOURNAL OF JISHOU UNIVERSITY(NATURAL SCIENCE EDITION);2000-01
6 Xin Shantian;Geng Changshan;Zhou Jinhuang Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences;IMMUNOPHARMACOLOGICAL RESEARCH AND USAGE OF ACTIVE INGREDIENT OF TONICS IN TRADITIONAL MEDICINE[J];Bulletin of the Academy of Military Medical Sciences;1988-03
7 Zhou Jinhuang (Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences);THE ANTI-AGING AND IMMUNOMODULATING EFFECTS OF CHINESE HERBAL DRUGS EPIMEDIUM(YINYANGHUO)AND POLYGONUM(HESHOUWU)[J];Bulletin of the Academy of Military Medical Sciences;1991-04
8 Lv xiang1,Wu Jingfeng2,Yi Tingjiao3,Ling Changquan 1,Shanghai municipal hospital of traditional 200071;2.The fudan university,Shanghai huashan hospital 200040;3.The second military medical university,Shanghai 2507111 changhai hospital subsidiary of Shanghai university of TCM;4.Shanghai institute of internal E 201203;Epimedium inhibited chick embryo chorioallantoic membrane angiogenesis research[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2010-06
9 CHEN Yonggang,LIU Xiaohan,LIN Li,OU Jiming,XIAO Fengxia,LUO Suihong (School of Chinese Herbal Medicine,Guangzhou University of TCM,Guangzhou 510006 Guangdong,China);Optimization of Assay Methods for Total Flavonoids in Herba Epimedii[J];Journal of Guangzhou University of Traditional Chinese Medicine;2009-03
10 Ye Chun Lio Dao-De Lilian SongJun Wang Fan (Department of anatomy, School of Preclinical and Forensic Medicine, Sichuan University ,Chundu 610041, China);Epimedium prevent ovariectomy-induced osteoporosis in rats[J];Sichuan Journal of Anatomy;2004-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Jiang Xiang-kun1 Liu Min-ru2(1Shenzhen Maternity and Child Health Hospital Affiliated to Southern Medical University,Guangdong Shenzhen 518028;2 Chengdu University of Traditional Chinese Medicine,Si Chuan Chengdu 610075);Effects of Pharmacological Serum Containing Bushenfufang Capsule on Proliferation,Differentiation and Mineralization of Osteoblasts in Vitro[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-01
2 SHANG Chuan-chuan1,ZHAO Yi2,MU Yang1,LIANG Ning1,ZHOU Li-mei1,QIU Ming-ning1,WANG Xiao-kun1,LI Nan1(1.College of Veterinary Medicine,Northwest A & F university,Yangling,Shaanxi,712100,China;2.Shaanxi Animal Husbandry & Veterinary Bureau,Xi'an,Shaanxi,710003,China);Effects of Epimedium Polysaccharide on Immune Organs and Immune Effects of Newcastle Disease Vaccine[J];Progress in Veterinary Medicine;2009-04
3 DONG Hong-Juan~(1,2),LIU Zhi-Qiang~(1*),SONG Feng-Rui~1,YU Zhan~1,LI Hui-Lin~1,LIU Shu-Ying~1(1.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun Center of Mass Spectrometry,Changchun 130022,China;2.Graduate School of the Chinese Academy of Sciences,Beijing 100049,China);Studies on Paeoniflorin by Electrospray Ionization Tandem Mass Spectrometry[J];Chemical Journal of Chinese Universities;2006-11
4 ZHU Jing-bo1,LI Dan-feng1,QIU Huan-jie1,WANG Long-xing2,XIAO Hong-bin21.School of Biological & Food Engineering,Dalian Polytechnic University,Dalian 116034,China;2.Dalian Institute of Chemical Physics,Chinese Academy Sciences,Dalian 116023,China;HPLC/ESI-MS analysis of flavonoids in Epimedium extract[J];Journal of Dalian Polytechnic University;2009-05
5 MENG Ning,KONG Kai,LI Shi-weng(School of Chemical and Biological Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China);Advances in Studies on Chemical Constituents and Pharmaceutical Activities in Species of Epimedium[J];Acta Botanica Boreali-Occidentalia Sinica;2010-05
6 ZHAN Li-ping1,ZHAO Xin2,ZHANG Jian-jun1,LIU Zhi-mei1(1.Vocation Technical College of Liaoning University of Traditional Chinese Medicine,Shenyang 110101,Liaoning,China;2.Liaoning Forestry Vocation-Technical College,Shenyang 110101,Liaoning,China);Status and Prospect of Research on Medicinal Plants of Epimedium L.[J];Journal of Liaoning University of Traditional Chinese Medicine;2007-03
7 Li Jian;Ye Chun;Liu Dao-De;Wang Fan Department of Anatomy School of Preclinical and Forensic Medicine Sichuan University Chengdu 610041 China;The effects of serum containing Epimedium in the bone organ culture of SD rat in vitro[J];Sichuan Journal of Anatomy;2004-02
8 FENG Nian-ping1 DU Guang-li1 DI Bin2 LIU Wen-ying2 1. Shanghai University of Traditional Chinese Medicine; 2. China Pharmaceutical University;Discussion of the Compatibility-Metabolism Correlations of TCMs[J];Shanghai Journal of Traditional Chinese Medicine;2007-10
9 SONG Li1 XU Lu-yang2 ZHANG Ning1 1. Shanghai University of Traditional Chinese Medicine 2. Huashan Hospital Affiliated to Fudan University;Effects of Intestinal Bacteria on Metabolism of Glycyrrizin in Rats[J];Shanghai Journal of Traditional Chinese Medicine;2008-09
10 Wang Qiao, Liu Rongxia and Guo Dean ( Modern ResearchCenter of Traditional Chinese Medicine, Peking University, Beijing 100083 ) Bi Kaishun ( Shengyang University of Materia medica , Shengyang 110016, Liaoning Province of China );Present Situation and Prospects of Studies on Metabolism of Traditional Chinese Medicine[J];;2003-06
China Proceedings of conference Full-text Database 2 Hits
1 Nian-Ping Feng1, Bin Di2 and Wen-Ying Liu2 1 Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China 2 China Pharmaceutical University, Nanjing 210009, P. R. China;Discussion of the Compatibility-Metabolism Correlations of TCMs[A];[C];2006
2 DOU Jian-peng, LIU Zhi-qiang, LIU Shu-ying(1. Laboratory of New Drug Research, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; 2. College of Biological and Agricultural Engineering, Jilin University, Changchun 130025, China);Analysis of Two Flavonol Glycoside Isomers by Electrospray Ionization Tandem Mass Spectrometry[A];[C];2004
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