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《Medical Information》 2018-21
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Bioinformatics Analysis of the Susceptible Genes of Psoriasis

ZHENG Wen-Xin;LIU Hong;WANG Wei;Capital Medical University School of Biomedical Engineering;Central Laboratory of Capital Medical University;  
Objective To analyze the functional enrichment of psoriasis susceptible genes and screen the key susceptible genes.Methods According to the OMIM database and the published articles in recent years,the susceptibility genes of psoriasis were collected,and the susceptibility genes were enriched and analyzed by Gather online service. The protein interaction network was constructed by using the String database, and the key susceptible genes were screened. Results The function of susceptibility gene of psoriasis is mainly enriched in immune response, defense response, biological stress response, organic physiological process, stress response, response to insect parasite pathogens, response to external biological stimuli, response to trauma, antigen expression, antigen presentation and antigen processing. By calculating the degree of the nodes in the protein interaction network encoded by the susceptibility genes, we selected the first 10 genes, as the key susceptible genes. Both the functional analysis and pathway analysis suggested that the key genes interact with the many genes related to psoriasis. Conclusion Susceptibility gene analysis indicates that psoriasis is a hereditary immune skin disease, closely related to environmental factors. Protein interaction network analysis suggests that though some key susceptible genes do not have definite functions, but they interact with a lot of genes with specific functions associated with psoriasis.
【Fund】: 基础临床课题(编号:16JL85);; 北京市自然科学基金(编号:5182006)
【CateGory Index】: R758.63
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