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《Journal of New Medicine》 2019-02
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Application of Adipose Derived Mesenchymal Stem Cells in the Treatment of Chronic Obstructive Pulmonary Disease

Huang Zhiang;Shang Yan;Liu Fangfang;Department of Respiratory Medicine,The First Affiliated Hospital of Henan University;  
Objective To explore the application value of adipose derived mesenchymal stem cells(ADMSCs)in chronic obstructive pulmonary disease(COPD).Methods 60 SPF male rats were randomly divided into control group,observation group and model group with 20 rats in each group.COPD rat models were established in observation group and model group by passive cigarette smoking and intratracheal instillation of endotoxin, while non model was established in control group. After modeling,rats in observation group were injected with 0. 5 ml of BrdU labeled ADMSCs suspension through caudal vein,while rats in control group and model group were injected with 0.5 ml of normal saline through caudal vein.Lung function,levels of inflammatory factors and pathological changes of lung tissue in rats were determined at 14 d after transplantation.Results Compared with the control group,the indexes of lung function decreased significantly in model group and observation group(P0.05),and lung function in observation group was better than that in model group(P0.05).The number of total white blood cells,number of macrophages and neutrophils,levels of interleukin 8,tumor necrosis factor and C reactive protein in bronchoalveolar lavage fluid of the model group and observation group were significantly higher than those in control group(P0.05).The number of immune cells and levels of inflammatory factors in observation group were significantly lower than those in model group(P0.05).Pathological changes of COPD in the lung tissue sections of model group and observation group were observed.Emphysema symptoms in observation group were milder than those in model group(P0.05).Conclusion ADMSCs transplantation can sig nificantly improve pathological changes of lung tissues in COPD rats,relieve inflammatory reaction and improve lung function.
【CateGory Index】: R563.9
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Chang Pengyu;Xia Chengcheng;Hou Xue;Shi Weiyan;Song Yuzhe;Zhang Yuyu;Zhao Qin;Ma Lixin;Qu Yaqin;Dong Lihua;Department of Radiation Oncology,First Bethune Hospital of Jilin University;;Infusion of mesenchymal stem cells limits fibrogenesis in irradiated rat lung[J];中华放射医学与防护杂志;2015-06
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Huang Zhiang;Shang Yan;Liu Fangfang;Department of Respiratory Medicine,The First Affiliated Hospital of Henan University;;Application of Adipose Derived Mesenchymal Stem Cells in the Treatment of Chronic Obstructive Pulmonary Disease[J];医学新知杂志;2019-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 SHEN Ge,WANG Fang,ZHANG Wei-jing,LIU Bing,YUAN Shun-zong,WANG Li,SHAO Yun.Department of Radiation Oncology,Affiliated Hospital to Academy of Military Medical Science,Beijing 100071,China;Mesenchymal stem cells reduce the irradiation induced lung injury[J];中华放射医学与防护杂志;2010-06
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