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《Journal of New Medicine》 2019-03
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Application of Dexmedetomidine in Non-positive Pressure Ventilation during Anesthesia Induction of Acute Intestinal Obstruction in Elderly Patients

Song Huiqiong;Peng Xiaohong;Chen Chang;Department of Anesthesiology,Wuhan Fourth Hospital;  
Objective To evaluate the security and efficacy of dexmedetomidine in non-positive pressure ventilation during rapid sequence induction of anesthesia in elderly patients with acute intestinal obstruction.Methods Sixty ASA Ⅰ ~Ⅲ patients scheduled for laparotomy under general anesthesia enrolled in this study.Patients were randomly divided into control group(group C),non-positive pressure ventilation group(group NM)and dexmedetomidine group(group Dex+NM)with 20 patients in each group.The levels of MAP,HR and PaO_2 were recorded at entering operating room(TO),tracheal intubation(T,)and 3 min after tracheal intubation(T_2).The incidences of hypotension,bradycardia and countercurrent mistake inhalation in induction period were also recorded.Epinephrine(E)and norepinephrine(NE)concentrations in peripheral blood at T_0,T_1 and T_2 were detected.Results There were no significant differences on HR,MAP,E and NE concentrations at T_1 and T_2 in group NM and group C(P0.05).Countercurrent mistake inhalation concentrations at T_0 and T_2 were lower in group NM and group Dex+NM(P0.05).MAP,HR,E and NE concentrations at T_1 and T_2 in group Dex+NM were significantly lower than those in group NM(P0.05).There were no significant differences on incidences of hypotension and bradycardia at T_0 and T_2 in these three groups(P0.05).There was no significant difference on PaO_2 at T_0,T_1 and T_2 in the three groups(P0.05).Conclusion Intravenous pre-infusion of dexmedetomidine can increase patient's compliance of oxygen reserve,suppress the stress reaction at intubation and reduce the risk of countercurrent mistake inhalation during anesthesia induction in elderly patients with acute intestinal obstruction.
【CateGory Index】: R614
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