Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Shanghai Medical Imaging》 2005-01
Add to Favorite Get Latest Update

Evaluation of chronic ischemic myocardium before and after transplantation of bone marrow stromal cell transferred by angiogenin gene with three-dimensional echocardiography

XU Jing,ZHAO Baozhen,HUANG Shengdong, et al. Department of Ultrasound Changhai Hospital, The Second Military Medical University, Shanghai 200433, China  
Objective To evaluate the value of Dynamic Three-dimensional echocardiography (DTDE) in detecting chronic ischemic myocardium before and after transplantation of bone marrow stromal cells (BMSCs) combined with angiogenic gene(ANG) transfer. Methods Four weeks after chronic ischemic myocardium models were set up, groupⅠ,Ⅱ,Ⅲ and Ⅳ were intramyocardially administrated with BMSCs transferred by Adenovirus mediated ANG (Ad·ANG), Ad·ANG, BMSCs and null Adenovirus phosphate buffer respectively. Four weeks later, Pathological investigations were performed. The DTDE using TomTec reconstruction system at normal state, 4 weeks after Ameroid placement and 4 weeks after administration were performed to analysis the shape, volume and wall motion changes of left ventricle. Results Left ventrical (LV) remodeled and weakness of lateral-posterior wall (LPW) motion emerged 4w after Ameroid placement. The end-diastolic volume of left ventricle (EDV) were all increased and the ejection fraction (EF) all decreased (P0.01). After administration, group Ⅳ remained increased volume and decreased EF compared with that before administration (P0.05). GroupⅠ,Ⅱ and Ⅲ had improvement of LV remodeling, decrease regional EDV of LPW and increase EF (P0.05~0.01). The greatest increase of EDV in baseline and middle PW and that of EF in baseline PW were found in Group Ⅰ(P0.05). Conclusions DTDE is a feasible approach to assess regional LV volumes and systolic function changes in chronic ischemic myocardium before and after gene transfer and cell transplantation therapy.
【CateGory Index】: R541.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 ZHAO Bao-zhen, XU Jing, WANG Wei, et al. (Department of Ultrasound, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China);Evaluation of Chronic Ischemic Myocardium before and after Transplantation of Bone Marrow Stromal Cell Transferred by Angiogenin Gene by Real-time Myocardial Contrast Echocardiography[J];Technical Acoustics;2004-S2
2 XU Jing, ZHAO Bao-zhen, WANG Wei, et al. (Department of Ultrasound, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China);Assessment of Chronic Ischemic Myocardium before and after Transplantation of Bone Marrow Stromal Cell Transferred by Angiogenin Gene using Three-dimensional Echocardiography[J];Technical Acoustics;2004-S2
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 HUANG Yu-li,MAI Wei-yi. Department of Cardiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou510080,China;The potential molecular mechanisms of bone mesenchymal stem cells transplantation in cardiac regeneration[J];International Journal of Internal Medicine;2008-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved