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《Journal of Medical Research》 2013-07
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Analysis of Clinical Distribution and Drug Resistance of Gram-positive Cocci Isolated from the Neurology and Neurosurgery Department

Yang Peihong,Xu Xiuli,Sun Yiqun,Fan Xin,Liu Jiayun.Institute of Clinical Laboratory Medicine of People′s Liberation Army,Xijing Hospital,The Forth Military Medical University,Shaanxi 710032,China  
Objective To investigate the distribution and drug resistance against Gram-positive cocci from Neurology and Neurosurgery during six years,in order to provide laboratory data for clinical rational use of antibiotics.Methods Isolates were cultured by routine method and identified by the semi-automatic or automatic bacteria analysis system.The susceptibility testing was carried out according to a unified protocol of Kirby-Bauer method and results were analyzed according to CLSI standards.Data statistic and analysis used WHONET5.6 soft ware.Results Totally 1276 strains Gram-positive cocci were isolated in Neurology and Neurosurgery from 2006 to 2011,accounting for 21.06% of the Gram-positive cocci isolated from the whole hospital,of which there were Staphylococcus of 1016 strains(79.62%),Enterococcus 247 strains(19.36%),Streptococcus 13 strains(1.02%).Both of methicillin resistant strains in Staphylococcus aureus(MRSA) and Staphylococcus epidermidis(MRSE) accounted for 88.9%.We didn't found resistance to vancomycin,linezolid and teicoplanin against staphylococcia.The drug resistant rates of E.faecalis and E.faecium against teicoplanin were 2.6% and 0.7%.The drug resistant rates of E.faecium against vancomycin were 2.6%.We didn't found resistance to linezolid against Enterococcus.Conclusion MRSA which has high prevalence is one of the major pathogen in hospital infection.It is mandatory for hospitals to take effective control measures to prevent the spread of MRSA.
【CateGory Index】: R446.5
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