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《Journal of Medical Research》 2020-04
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Study on the Relationship between the Serum Lipid Level and Gestational Diabetes Mellitus in the Early Stage of Pregnancy

Lan Xueli;Chen Yi;Beijing Obstetrics and Gynecology Hospital,Capital Medical University;  
Objective To explore the relationship between blood lipid level in early pregnancy and gestational diabetes mellitus(GDM). Methods A total of 390 pregnant women who were enrolled in the Chinese birth population cohort project in Beijing Obstetrics and Gynecology Hospital from April 2018 to October 2018 were selected as the subjects of the study.The patients with GDM were the case group(n=64) and the patients with normal blood glucose were the control group(n=326).The levels of serum total cholesterol(CHO), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) were compared between the two groups.The relationship between the level of blood lipid level in early pregnancy and gestational diabetes mellitus was analyzed.Results Compared with the control group, the level of CHO,TG,LDL-C in pregnant women of pregnancy. The results of Logistic regression analysis show that the high level of CHO is a risk factor for pregnant women with gestational diabetes(OR=0.575,95%CI:0.358-0.923,P0.05). The results of Logistic regression analysis show that the high level of CHO is a risk factor for pregnant women with gestational diabetes mellitus. Conclusion There is a correlation between abnormal blood lipid related indexes in early pregnancy and the incidence of gestational diabetes mellitus. The level of CHO,TG,LDL-C in pregnant women with gestational diabetes mellitus is increased and the level of HDL-C is decreased in the early trimester of pregnancy. The monitoring and intervention of blood lipid in early pregnancy should be strengthened.
【Fund】: 国家自然科学基金资助项目(81571130090)
【CateGory Index】: R714.256
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