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《Journal of Medical Research》 2020-05
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Effect of Low-protein Diet based on Carbohydrate Counting on Patients with Early Diabetic Nephropathy

Wang Weiguang;An Linlin;Zhang Xiaoyan;Zhejiang Hospital;  
Objective To explore the effect of low protein diet based on carbohydrate counting on patients with early diabetic nephropathy. Methods A total of 99 subjects were included from Diabetes Center of China and the United States and Urology Department of Zhejiang Hospital from June 2017 to June 2018. Subjects were divided two group randomly. The control group was intervened by ordinary diet,experimental group was intervened by low-protein diet based on carbohydrate counting including dietary education and standard recipes of a weekly. We would follow-up by telephone once a week, and adjust the recipes of the experimental group according to the patient′s actual condition. Index of fasting blood-glucose(FPG), hemoglobin A1 c(HbA1 c), serum creatinine(Scr), blood urea nitrogen(BUN), glomerular filtration rate(GFR), urine albumin excretion ratio(UAER), triglyceride(TG), total cholesterol(TC), mean arterial pressure(MAP) were compared before and after 3 month of intervention. Results After the intervention, MAP, FPG, HbA1 c, TG reduced observably, and significantly lower in the experimental group than those in the control group. But there was no significant change in TC in both groups. After the intervention, the Scr, BUN, UAE were reduced observably, the GFR was increased observably in both groups, and there was statistic difference in the Scr, BUN, UAE, GFR in both groups. Conclusion Low-protein diet based on carbohydrate counting method can significantly ameliorated the blood glucose level, and promote the recovery of renal function of patients with early diabetic nephropathy.
【Fund】: 浙江省卫生厅培育项目(2014PYA002)
【CateGory Index】: R587.2;R692.9
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