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High-intensity focused ultrasound ablation for peripheral primitive neuroectodermal tumor clinical analysis cases

YANG Wu-wei, LI Jing, ZHOU Jie-min, et al Department of Minimally Invasive Tumor Therapies, 307 Hospital Affiliated to Academy of Military Medical Sciences, Beijing 100071, China  
Objective:To study on the clinical efficacy of high-intensity focused ultrasound ablation for pPNET. Methods:The Model-JC HIFU System (Chongqing HAIFU Company) was used in five cases of pPNET, among which four cases of verified treatment failure with remote metastasis or local recurrence, one previously untreated case. All the patients are male with age ranging from 10 to 28(median age of 20) and tumor size ranged from 6 to 25 cm in diameter, with a mean diameter of 11 cm. All adopt the comprehensive treatment involving the HIFU ablation, Applying MRI or CT to evaluate the effectiveness of local tumor ablation, and assessing overall survival time through follow-up review. Results:After treatment, tumors in four patients were completely ablated, while tumors in the rest one patient partially ablated. During the 3 years of follow-up, four patients are dead (overall survival time is 13-60 month with a median of 20.5 months) and one patient is still tumor free after 36-months follow-up. The median time to relapse is 6.5 months in four cases of local recurrence (range 2-10 months). Conclusion:HIFU can be used to efficiently treat the patients with pPNET. HIFU ablation combined with the other methods for pPNET is a new strategy and worthy of further exploration.
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