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《Medical Recapitulate》 2007-14
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Correlative Study between Mitochondrial Transmembrane Potential and Apoptosis

CHEN Hui-li1,LI Jian-hua1,WANG Shu-qing2.(1.Weifang Medical College,Weifang 261041,China;2.Affiliated Hospital of Weifang Medical College,Weifang 261031,China)  
Decreasion of mitochondrial transmembrane potential is a inreversible cases of early apoptosis.Decreasion in electric potential difference of exterior and interior mitochondria membrane can result in a series of biochemisry changes between exterior and interior mitochondria membrane,such as induction of cytochrome releasing,activity of caspase family,uncouple of respiratory chain and oxidative phosphorylation,cessation of ATP synthesis,alteration of mitochondria membrane permeability,releasing of apoptosis-inducing factor(AIF),and so on,which also results in apoptic cascade reaction and further results in cell apoptosis.This article reviews mitochondrial transmembrane potential about its formation,changes during cell apoptosis as well as its mechanism.
【Fund】: 山东省中医管理局科研基金资助课题(2003年第126号)
【CateGory Index】: R329
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