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《Medical Recapitulate》 2012-06
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Combined Analysis of S100A4 and S100A6 Expression in Gastric Cancer

LIU Jun-bin.(Department of General Surgery,Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010050,China)  
Objective To analyze the combined expression of S100A4 and S100A6 in the clinical pathologic features of gastric cancer.Methods Immunohistochemistry was performed in 78 gastric cancer tissues with S100A4 and S100A6 antibodies.Results In gastric cancer,high cytoplasmic S100A4 expression was seen in 42%(33/78)of the cases.High S100A4 expression was strongly associated with TNM stage(P=0.031).High S100A6 was seen in the nucleus and/or cytoplasm in 69%(54/78)tumors.High S100A6 expression was strongly associated with tumor size,depth of invasion and TNM stage.The result of combined analysis of S100A4 and S100A6 showed that S100A4+/S100A6+ was correlated with depth of invasion,positive lymph node metastasis and TNM stage.Conclusion Combined analysis of S100A4 and S100A6 can help analyze the biologic behavior of gastric cancer.
【CateGory Index】: R735.2
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