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《Medical Recapitulate》 2013-09
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Research Progress and Clinical Application of α-L-fucosidase

WU Man-dan,HUANG Qian-chuan.(Department of Laboratory Medicine,Wuhan General Hospital of Guangzhou Military Area,Wuhan 430070,China)  
The acid α-L-fucosidase(AFU) is usually found as a soluble component of lysosomes,the systematic name is α-L-fucosidase(EC3.2.1.51).It is involved in the hydrolytic degradation of fucose-containing molecules.AFU distributes in human tissues and body fluids,especially high concentration is seen in the liver and kidney.Alterations in the activity of AFU in serum or tissue have been observed in cancer.AFU is a significant index for the diagnosis,therapeutic effect and prognosis of hepatocellular carcinoma,pancreatic adenocarcinoma,and colon adenocarcinoma.
【CateGory Index】: R730.5
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