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《Medical Recapitulate》 2019-01
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Study on the Role of MicroRNAs in Lipid Metabolic Disorders

YU Xueting;XU Yushan;Department One of Endocrinology,the First Affiliated Hospital of Kunming Medical University;  
Blood lipid is important energy storage material of the body. Abnormal lipid metabolism can cause various diseases,such as obesity,dyslipidemia,and non-alcoholic fatty liver disease,which are risk factors for the occurrence and development of diabetes and cardiovascular diseases. In recent years,the incidence of lipid metabolic disorders has been on the rise. The traditional treatment methods are mainly lifestyle interventions and drug therapy,which have certain limitations. MicroRNAs( miRNAs) are a group of small,non-coding genes that can promote or inhibit the differentiation of adipocytes while participating in the biosynthesis of triacylglycerol( TG),cholesterol,and the like. The correlation of miRNA with obesity,low density lipoprotein cholesterol,high density lipoprotein cholesterol,TG,and non-alcoholic fatty liver disease suggests that miRNA may be a diagnostic marker and therapeutic target for lipid metabolism disorders and thus provide new possibilities for the prevention and treatment.
【Fund】: 云南省科技计划项目(2017FE468[-044])
【CateGory Index】: R589.2
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