Clinical Significance of Autoantibodies in Systemic Sclerosis
LIU Hehui;DENG Danqi;Department of Dermatology,the Second Affiliated Hospital of Kunming Medical University;
Systemic sclerosis( SSc) is one of the common autoimmune connective tissue diseases. The etiology is not clear. The main pathogenesis is immune dysregulation,vasculopathy,excessive fibrosis of skin and visceral organs. Immune dysregulation produces various circulating autoantibodies which target against their own tissues,cells or components.Furthermore,these autoantibodies usually are produced in early course of the disease before its clinical manifestations. A great deal of studies have found that more and more autoantibodies are significantly correlated with the heterogeneous clinical manifestations,disease process,complications and prognosis of SSc. Therefore,to summarize the clinical significance of SSc-related autoantibodies is particularly important for the early diagnosis,evaluation,complication prediction and prognosis of SSc.
【CateGory Index】： R593.2