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《China Medical Herald》 2007-22
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Establishment of rat model of allergic asthma and the effect of desamethasone on it

WANG Yong-sheng1,GUI Shu-yu2,LI Yong-huai2 (1 Respiratory Department,Chaohu First People′s Hospital,Chaohu 238002,China; 2 Respiratory Department,The First affiliated Hospital of Anhui Medical University,Hefei 230022,China)  
Objective: To establish the rat model of allergic asthma,and study the effect of desamethasone on it. Methods: Twenty-four rats were divided randomly into control group (group A),asthma group (group B),and desamethasone (DXM) group (group C). Asthma rat model was established by sensitization and challenge with ovalbumin (OVA). One hour prior to OVA challenge,the rats in group C were intraperitoneally injected with DXM 0.5 mg/kg. The model was identified by the study of the total white cells and eosinophils counts in bronchoalveolar lavage fluid (BALF),The hematoxylin and eosin (HE) stain of lung histologic section of rats. Results: The number of total white cell,eosinophils in BALF in group B was significantly higher than that in group A and group C (P0.01). Lung histopathologic slides of group B were bronchial constriction,part of epithelium shedding,characteristic of inflammatory cell such as eosinophils infiltration around the airways and blood vessels. But only a few of same cells were found infiltration around the airways and blood vessel in group C,and no abnormality was found in group A. Conclusion: The rat model of allergic asthma is established successfully,and desamethasone can relieve asthma attack.
【CateGory Index】: R562.25
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