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《China Medical Herald》 2007-22
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Establishment of rat model of allergic asthma and the effect of desamethasone on it

WANG Yong-sheng1,GUI Shu-yu2,LI Yong-huai2 (1 Respiratory Department,Chaohu First People′s Hospital,Chaohu 238002,China; 2 Respiratory Department,The First affiliated Hospital of Anhui Medical University,Hefei 230022,China)  
Objective: To establish the rat model of allergic asthma,and study the effect of desamethasone on it. Methods: Twenty-four rats were divided randomly into control group (group A),asthma group (group B),and desamethasone (DXM) group (group C). Asthma rat model was established by sensitization and challenge with ovalbumin (OVA). One hour prior to OVA challenge,the rats in group C were intraperitoneally injected with DXM 0.5 mg/kg. The model was identified by the study of the total white cells and eosinophils counts in bronchoalveolar lavage fluid (BALF),The hematoxylin and eosin (HE) stain of lung histologic section of rats. Results: The number of total white cell,eosinophils in BALF in group B was significantly higher than that in group A and group C (P0.01). Lung histopathologic slides of group B were bronchial constriction,part of epithelium shedding,characteristic of inflammatory cell such as eosinophils infiltration around the airways and blood vessels. But only a few of same cells were found infiltration around the airways and blood vessel in group C,and no abnormality was found in group A. Conclusion: The rat model of allergic asthma is established successfully,and desamethasone can relieve asthma attack.
【CateGory Index】: R562.25
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 Yuan Yiming *, Wang Zengli, Dong Birong. *Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China;Modulation of Matrix Metalloproteinase by Dexamethasone in Airway Remodeling in Asthmatic Rats[J];Journal of Sichuan University (Medical Sciences Edition);2003-04
2 Miao Hui Xue Quanfu* Zhuang Fengyuan(Hemorheology Department, ChinaJapan Friendship Institute of Medical Scinences,Beijing 100029);Establishment of Asthmatic Model of Rats[J];BASIC MEDICAL SCIENCES AND CLINICS;1998-01
3 DAI Jihong, TAN Yi, FU Zhou (Children's Hospital of Chonqing University of Medical Science, Chonqing 400014,China);The Current Situation of Researches on Animal Model of Asthma[J];Chinese Journal of Laboratory Animal Science;2001-03
4 LI Chaoqian,XU Yongjian,ZHANG Zhenxiang,YANG Danlei,LIU Xiansheng, XIONG Weining Department of Respiratory Disease, Tongji Hospital,Tongji Medical College, Huazhong Science and Technology, Wuhan 430030,China;An experimental study of the effect of bacille almette-guerin vaccine on the production of a rat asthmatic model and its relation withγδT cells[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2002-03
5 LUO Feng-ming *,WANG Zeng-li,LIU Xiao-jing,LIU Chun-tao,ZHANG Xiao-hong,WANG Wen-zhi. *Department of Respiratory Disease, Huaxi Hospital of Sichuan University, Chengdu 610041, China;Expression of Clara cell secretory protein in airways of rat asthma remodel[J];Chinese Journal of Internal Medicine;2003-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yu Qimei,Xin Jianbao Hefei City First People's Hospital,Hefei,230061;The effects of utilin's astragalus and yuxingcar injection by acupoint-injection to control asthma atack in petients with asthma in remission[J];Anhui Medical Journal;2003-02
2 Liu Hua, Wang Xianyi Department of Respiratory Medicine, People's Hospital of Maanshan City, Anhui 243000;Measuring to peripheral blood EOS courting, serum ECP, GM-CSF density of bronchial asthma and analysis of its clinical significance[J];Anhui Medical Journal;2004-04
3 ZHAO Yong-chang (Department of Pediatric,Anhui Wuhe County People’s Hospital,Bengbu 233300,China);Clinical effect of salbutamol in treatment of bronchiolitis[J];Journal of Bengbu Medical College;2006-04
4 LIU Xiao ping, LUAN Gui zhen, SONG Ji ying, et al\ (Departme nt of Pediatrics, Qingdao Hiser Hospital, Qingdao 266033, China)\;;THE CHANGES OF SERUM SOLUB LE C5b-9 CONCENTRATION AND CLINICAL SIGNIFICANCE IN CHILDREN WITH ASTHMA[J];Acta Acadimae Qingdao Umvesitatis;2003-04
5 Zhou Yabing Xinhua Hospital Attached to Medical College of Shanghai Jiaotong University(200127);Syndrome Differentiation and Treatment in Children Cough Variant Asthma[J];Journal of Zhejiang University of Traditional Chinese Medicine;2008-01
6 Chen Shujun; Wu Dunxu; Zhaori Getu et al(School of Basic Science, Shanghai University of Traditional Chinese Medicine, Shanghai 200032);Effect of Supplemented Six Noble Decoction (Jia Wei Liu Jun Zi Tang) on Adrenergic Receptor and cAMP Content of the Lung Tissue in Asthmatic Rats[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1998-01
7 Chen Shujun; Wu Dunxu; Zhaori; Getu et al.(School of Basic Science, Shanghai University ofTraditional Chinese Medicine, Shanghai 200032);Effect of Supplemented Six Noble Decoction(Jia Wei Liu Jun Zi Tang)on Glucocorticoid Receptor of Lung Tissue in Asthmatic Rats[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1998-01
8 Liu Han Wang Lining Huang Xiaoqi Liang Liying(The First Hospital Affilliated to Guangxi College of Traditional Chinese Medicine,Nanning 530023);Effect of Liuweidihuang Granula Cooperating with Flixotide Aerosol on IFN-γ and IL-4 of Asthma Rat Models[J];China Journal of Traditional Chinese Medicine and Pharmacy;2006-09
9 Yang Shuo Cui Hongsheng He Fenghua Wu Weiping Wang Shuoren Ren Chuanyun(Department of Respiratory Medicine,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100700);Effect of Three-stage Sequential Method on Hypothalamic-Pituitary-Adrenal Axis in Asthmatic Rat Models after Steroid Intervention[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-03
10 ZHANG Jian-jun1,YANG Zhi-hui1,PANG Bao-sen2,WANG Lin-yuan1,WANG Lian-yun3,ZHUANG Wei1,LONG Rui1,DENG Xiao-ying1(1Basic Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100029,China;2 Institute of Respiratory Disease,Beijing Chaoyang Hospital Afflicated to Capital University of MedicalScience,Beijing 100020,China;3 College of Life Science,Shanghai Jiao Tong University,Shanghai 200030,China);Effect and mechanism of Shuang Long Capsule on asthmatic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-12
China Proceedings of conference Full-text Database 7 Hits
1 Wei Qingyu, ye Jing, Zhang Ping,et al .Department of Allergy Diagnosis, No .202 Hospital of PLA shenyang 110003;The expression of asthma white rat bronchus epithelia and the effect of content of IL-5 in BALF by prescription and medicine of strengthening spleen and benefiting Vital Qi[A];[C];2002
2 Wei Qingyu, Department of Allergy Diagnsis,No.202 Hospita of Shenyang Military Area, Shenyang 1 10003, Li Gang, Department of Intemal Medicine of Liaoning College of TCM;The expression of asthma white rat bronchus epithelia ICAM-1 and the effect of content of IL-5 in BALF by prescription and medicine of strengthening spleen and benefiting Vital Qi[A];[C];2002
3 Wei Qingyu Dong Rui Yang Chunshan Zhu Xiaoming Wang Wei.Allergic reaction section,202 Hospital,Shenyang Military Command(110003);The Study on Change and Correlation Of IL-5,GM-CSF,TNF-α and sIL-2R in BALF in Asthmatic Rat and The Effect of Their Contents by Add Ingredients Jade Screen Powder.[A];[C];2007
4 ZHU Xiao-ming1,YANG Yue-yan2,WANG Wei1,PIAO Ren-fan3,WEI Qing-yu1. 1 Department of Allergy Diagnosis,No.202 Hospital of Shenyang Military Area,110003.2 Department of medicament,Liaoning Provincial Institute of TCM,110034.3 Yanbian University of TCM 133000;The influnce of the mothod of “reinforcing the spleen to replenish QI” on the level of cyclic nucleoside of the rat asthmatic models with spleen-deficiency[A];[C];2009
5 WEI Qing-yu~1 YANG Chun-shan~2 ZHUN Xiao-ming~1 TAN Wen~1 WANG Wei~1 PIAO Ren-fan~3 1 Allerdic reaction section,the 202th Hospitial,Shenyang Military Command,Shenyang 110003;2 Changchun Rheumatism Hospital of university of Troditional Chinese medicine,Changchun 130021;3 Troditional Chinese Medicine college of Yanbian university, Yanji 133000;The expression of the content of Totle IgE,IL-4,and IFN-γin asthma white rat blood serum by augmented jade screen powder[A];[C];2009
6 Li Gang Liu Chun Liaoning College of TCM Shenyang 110032 Wei Qingyu 202 Hospital 110003;The effects of Chinese herbs with replenishing splenn qi on the content of IL-4 and IFN-γin the serum of asthmatic white rat[A];[C];1999
7 MA Zuoying1,YUAN Weiling1,HE Shan2(1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Tianjin TEDA Hospital,Tianjin 300357,China);The Effect on IFN-γ and IL-4 of Asthma in Serum and BALF of Rats Treated by the Method of Dispersing Lung Qi and Invigorating Spleen Qi[A];[C];2011
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LI Tong-ming,SUN Zhi-jia,LIU Xiao-hong,LIANG Zhi-ying (Staff Room of Traditional Chinese Medical Formulae, Guangzhou University of Traditional Chinese Medicine, Guangdong Guangzhou 510405, China);Clinical Study on Effect of Dingchuan Decotion on Paroxysmal Asthma of Heat Type[J];Journal of Anhui Traditional Chinese Medical College;2005-01
2 Hu keming (Shengsi Peop1e's Hospital, Shengsi 202450);Clinical Analysis of 100 Patients with Disease due to Wind-Warm and Lung-Heat[J];Journal of Zhejiang College of Tcm;1995-03
3 Han Guodong et al. (Tianjin College of TCM, Tianjin);Observation on the Restoration-Promoting Effect of Major Chengqi Decoction on Experimental Pulmonary Damage[J];China Journal of Traditional Chinese Medicine and Pharmacy;1994-05
4 WU Xianzhe,Yang Shenglan.Luohu Hospital of Shenzhen,Shenzhen,Guangdong,518001,China;Effect of Constipation by Outlet Obstruction on the Content of Plasm Endotoxin and Serum Tumor Necrosis Factor-α of Rats[J];Journal of Coloproctological Surgery;2004-01
5 XIE Hua 1,2 , HE Shao Heng 1, CHI Xiu Li 2, CHEN Ping 2 1Institute of Allergy & Inflammation Research, Shantou University Medical College, Shantou 515031, China, 2Department of Respiratory Medicine, General Hospital, Shenyang Command, Shenyang 110015, China;Detection and correlation of tryptase, IL-8, eotaxin and chymase activity in plasma of patients with asthma[J];Journal of The Fourth Military Medical University;2004-16
6 YAO Yi-ming,YAO Jin-hui(Donghua Hospital of Dongguan,Guangdong Dongguan 523110,China);The Effect of Shuxuening Injection on Pulmonary Function of Patients with Bronchial Asthma[J];Hebei Medicine;2009-02
7 LUO Bai ling, WU E sheng, QIU Wan fu, HAI Zhen huan Department of Internal Medicine, Xiangya Hospital, Hunan Medical University(Changsha 410008) [;Expression of interleukin 5 and interleukin 10 and their relationship in asthma[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;2000-02
8 ZHANG Wei-dong(Institute of Guangzhou Respiratory Diseases,Guangdong 510110,Guangzhou China);Relationship Between Asthmatics and Total Plasma IgE Levels in Asian Population[J];Journal of Elinical Research;2005-01
9 ;Clinical Observation on the Treatment of 42 Cases of Variant Asthma With Combination of Traditional Chinese and Western Medicine[J];;2005-01
10 ;Clinical Observation on the Treatment of 35 Cases of Bronchial Asthma Paracme With Strengthening Earth to Generate Metal Method[J];Guiding Journal of TCM;2006-01
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 CUI Long ping ,YANG Yong qing ,CHEN Han ping, MA Shu lan, ZHANG Ying ying (Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China);Establishment of Allergic Asthma Model in Rat[J];SHANGHAI LABORATORY ANIMAL SCIENCE;2000-02
2 LI Shujun,QI Haowen,DI Xinyu Department of Respiratory Disease, Xijing hospital, Fourth Military Medical University, Xi′an 710032,China;The role of dexamethasone on airway wall remodeling[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2001-03
3 Xue Jianmin, Xu Yongjian, Zhang Zhenxiang, et al. Department of Respiratory Disease, Tongji Hospital, Tongji Medical University, Wuhan 430030;Effects of nitric oxide on the airway inflammation and lymphocyte proliferation in sensitized rats[J];CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES;1998-04
4 Zhao Menghui; Zhang Lifen; Zhang Weiping(Laboratory of Neurobiology, Zhejiang Medical University);A MODEL OF AIRWAY ALLERGIC INFLAMMATION IN THE SD RATS[J];;1997-03
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