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《China Medical Herald》 2009-19
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Pharmacokinetics analysis of icariin in rats coming from Chinese medicine compound recipe and single medicinal materials

DUAN Xuguang,ZHOU Chongwen,CHEN Ke,ZENG Lei (Hunan Environment and Biologic Polytechnic,Hengyang 421005,China)  
Objective:To compare the difference of kinetic parameter of medication-metabolism in rats of the icarrin,which come from compound recipe and single medicinal materials using RP-HPLC,and disscuss the influence of compatibility of medicines to body. Methods:The rats were intragastric administered with compound recipe and extractive of Longspur Epimedium respectively. The blood concentration of different time points were tested by proposed established RP-HPLC. Data were dealed with pharmacokinetic programme,and fitted to kinetic parameter. It showed that icarrin in the compound recipe was in two-chamber in mouse,and single medicinal materials in one-chamber. Results:Main kinetic parameters were that compound group was Cmax=(3.133±0.290) μg/ml,t1/2(Ka)=(0.753±0.809) h,Tmax=(2.089±0.144) h,AUC0-24=(30.839±3.680) μg·h/ml. Single medicinal materials group was Cmax=(2.318±0.218) μg/ml,Tmax=(1.497±0.521) h,AUC0-24=(19.947±2.555) μg·h/ml. Conclusion:The results show that there are some significance differences of icariin between the compound recipe and single herber. The elimination,absorption,peak time of icariin in the compound recipe are higer than in Longspur Epimedium.
【Key Words】： Pharmacokinetics Longspur Epimedium Icariin HPLC
【CateGory Index】： R285
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