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《China Medical Herald》 2009-22
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The effect of Yiqihuoxue Chinese Herbal Medicine on amino acid contents in brain tissue of rats after cerebral ischemia-reperfusion

ZHANG Xinchun1, LU Guangyao1, QIN Xiude2 (1.Department of Neurology, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China; 2.Guangzhou University of TCM, Guangzhou 510405, China)  
Objective: To discuss the protective effect and mechanism of Yiqihuoxue Chinese Herbal Medicine (Xiongqi Composition) on amino acid contents in brain tissue of rats after cerebral ischemia-reperfusion. Methods: 30 rats were randomly divided into three groups: sham-operated group, model group and Xiongqi Composition treatment group. The ischemia-reperfusion injury model was established, then the amino acid contents in rat brain tissue of ischemia-reperfusion were determined. Results: Xiongqi Composition treatment group showed significant difference in the contents of excitatory amino acids Glu and Asp in the brain tissues after ischemia-reperfusion compared with the model group, but it showed no significant difference compared with the sham-operated group, suggesting Xiongqi Composition could inhibit the increase of excitatory amino acids Glu and Asp contents of ischemia side brain tissue induced by ischemia-reperfusion in rats, and could cause them tend to normal. Xiongqi Composition treatment group showed significant difference in inhibitory amino acides Gln and GABA in brain tissues after ischemia-reperfusion compared with model group and sham-operated group, suggesting Xiongqi Composition could also increase the contents of inhibitory amino acids Gln and GABA in brain tissues after ischemia-reperfusion. Conclusion: Xiongqi Composition can reduce cerebral ischemia-reperfusion injury by adjusting the contents of excitatory amino acids and inhibitory amino acids.
【CateGory Index】: R285.5
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