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《China Medical Herald》 2011-18
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Effects of Penehyclidine Hydrochloride on apoptosis of myocardial cells induced by ischemia-reperfusion of bi-hind limbs in rats

ZHANG Xiongfei,PAN Daobo Department of Anesthesiology,the First People′s Municipal Hospital of Changde,Hunan Province,Changde 415000,China  
Objective: To investigate effects and mechanisms of Penehyclidine Hydrochloride on apoptosis of myocardial cells induced by ischemia-reperfusion of bi-hind limbs in rats.Methods: Sixty rats were randomly divided into 3 group: sham-operated control(C)group,ischemia-reperfusion(H)group and Penehyclidine Hydrochloride+ischemia-reperfusion(M)group.The cardiac histopatholopic changes in experimental rats were observed.Immunohistochemical studies and TUNEL were done to evaluate the expression of Bax,Bcl-2and the apopt-osis index.Contents of MDA,MPO,IL-10,TNF-α and the activity of SOD in myocardium and the survival rate in 24 hours were measured.Results: In H group: the apoptosis index,the expression of Bax and the contents of MDA,MPO,TNF-α,IL-10 were significantly increased compared with the other two groups,and under light microscope,myocaedial impairment was worst.The activity of SOD and the survival rate of rats significantly decreased compared with C group.In M group: the cardiac histopatholopic changes were better than H group,and the survival rate,the contents of IL-10,the activity of SOD significantly increased.The contents of MDA,MPO,TNF-α significantly decreased compared with H group.Conclusion: Penehyclidine Hydrochloride can protect the myocardium from bi-limb ischemia-reperfusion,extenuate apoptosis of myocardial cells,and the protective effects may be related to antioxidation and inhibition of inflammatory response.
【CateGory Index】: R965
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