Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《China Medical Herald》 2011-18
Add to Favorite Get Latest Update

Effects of Penehyclidine Hydrochloride on apoptosis of myocardial cells induced by ischemia-reperfusion of bi-hind limbs in rats

ZHANG Xiongfei,PAN Daobo Department of Anesthesiology,the First People′s Municipal Hospital of Changde,Hunan Province,Changde 415000,China  
Objective: To investigate effects and mechanisms of Penehyclidine Hydrochloride on apoptosis of myocardial cells induced by ischemia-reperfusion of bi-hind limbs in rats.Methods: Sixty rats were randomly divided into 3 group: sham-operated control(C)group,ischemia-reperfusion(H)group and Penehyclidine Hydrochloride+ischemia-reperfusion(M)group.The cardiac histopatholopic changes in experimental rats were observed.Immunohistochemical studies and TUNEL were done to evaluate the expression of Bax,Bcl-2and the apopt-osis index.Contents of MDA,MPO,IL-10,TNF-α and the activity of SOD in myocardium and the survival rate in 24 hours were measured.Results: In H group: the apoptosis index,the expression of Bax and the contents of MDA,MPO,TNF-α,IL-10 were significantly increased compared with the other two groups,and under light microscope,myocaedial impairment was worst.The activity of SOD and the survival rate of rats significantly decreased compared with C group.In M group: the cardiac histopatholopic changes were better than H group,and the survival rate,the contents of IL-10,the activity of SOD significantly increased.The contents of MDA,MPO,TNF-α significantly decreased compared with H group.Conclusion: Penehyclidine Hydrochloride can protect the myocardium from bi-limb ischemia-reperfusion,extenuate apoptosis of myocardial cells,and the protective effects may be related to antioxidation and inhibition of inflammatory response.
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ;Progress on clinical application of a new selective anticholinergic agent,penehyclidine hydrochloride[J];Chinese Journal of Industrial Medicine;2008-01
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 LIU Mei-mei,WANG De-ming,WANG Jia-zheng,et al(Paediatrics Department,the Second Affiliated Hospital of University of South China,Hengyang,Hunan 421001,China);Clinical Adjuvant Effect of Penehyclidine Hydrochloride on Children With Virus-associated Wheezy Bronchitis[J];Journal of Medical Science in Central South China;2011-01
2 LI Jin-xiu1,XU Rong-ting1,WANG Ying1,YANG Gang-san2,FENG Dong-xin3(1. Department of Emergency,Second Hospital of Shandong University,Jinan 250033,China; 2.Shandong Lunan Chemical Engineering Succor Center,Tengzhou 277500,Shandong,China; 3. Department of Emergency,Linzi Qidu Hospital,Zibo 255400,Shandong,China);Effect of hydrogen sulfide on cardiovascular injury induced by penehyclidine hydrochloride[J];Journal of Shandong University(Health Sciences);2010-01
3 WU Ying.(Department of Anesthesiology,Linxiang People's Hospital,Linxiang 414300,China);Clinical Observation of Penehyclidine Hydrochloride as the Preanesthetic Medication for Reducing the Occurrence of Restlessness in the Awaking Stage of General Anesthesia[J];Medical Recapitulate;2009-14
4 Si Jian-luo1, Song Shao-tuan1, Chang Sheng2 1Department of Anesthesiology, First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, Henan Province, China; 2Institute of Organic Transplantation, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China;Protective effects of penequinine hydrochloride on acute lung injury induced by orthotopic liver transplantation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-18
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LI Jin-jun, CHEN Jin-hua. Emergency Department of Changzhi People's Hospital, Shanxi Province. Changzhi 046000, China;Management of acute organophosphorus pesticide poisoning with penehyclidine hydrochloride[J];Disease Surveillance;2006-12
2 XU Li-yang~*,LI Jing-yu,ZHANG Qiang,LIU Tao,LIU Ming(Department of Radiology,Beijing Army General Hospital,Beijing 100700,China);Application of penehyclidine hydrochloride injection before interventional procedure[J];Chinese Journal of Interventional Imaging and Therapy;2006-06
3 CAO Feng-sheng1, HAN Ji-yuan1, TIAN Zhao-xing21. Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei China2. Department of Emergency, Peiking University Third Hospital, Beijing China;Effects of Penehyclidine Hydrochloride on the Expression of Nuclear Factor-κB in Rats After Acute Global Cerebral Ischemia/Reperfusion[J];Lingnan Journal of Emergency Medicine;2006-01
4 HE Zhi-jie, LIN Xiao-hong, HUANG Zi-tong Department of Emergency, the 2nd Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120;Clinical Study of Penehyclidine Hydrochloride on Patient with Septic Shock[J];Lingnan Journal of Emergency Medicine;2006-06
5 Ma Yuying,Li Guihua,Zhou Rong(First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,832008);Effect of Penehyclidine on treating organophosphorus pesticide poisoning[J];Journal of Nongken Medicine;2006-04
6 Huang Jun(Affiliated Xiehe Hospital of Tongji Medical College Huazhong Science and Technology University, Hubei 430022 China);Influence of atomization inhalation of penehyclidine hydrochloride on breathing mechanics in patients undergoing mechanical ventilation[J];Chinese Nursing Research;2006-13
7 Zhao Yaqin Li Wei Zhang Zhengni et alDepartment of Anesthesiology, the Second Hospital of Xi'an Jiaotong University (Xi'an 710004);The effect of penehyclidine hydrochloride on hemodynamics and i-pH of patients of replacement of mitral valve[J];Shaanxi Medical Journal;2006-09
8 FU Wen-xin,YANG Xiao-xu,WANG Yun-ming(Department of Anesthesiology the Second Hospital of Tianjin,Tianjin 300141,China);The clinical observation of administration of penehyclidine hydrochloride as premedication in abdominal surgery[J];Journal of Tianjin Medical University;2005-04
9 Zhou Daixing,Deng Puzhen Department of Emergency, Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030;The Changes in [Ca~(2+)]_i and the Ultrastructure of Cortex after Acute Complete Cerebral Ischemia and Reperfusion and the Effects of Anisod amine in Rabbits[J];Journal of Tongji Medical University;2001-06
10 Nan Jiayan~1,Gao Xiaoyan~2,Li Huiling~1,Yang Jiwei~1(1.Department of Emergency,the First Affiliated Hospital,Medical School of Xi'an Jiaotong Universty,Xi'an 710061;2.Department of Hygiene,Medical School of Xi'an Jiaotong University,Xi'an 710061,China);Clinical observation of the effects of long-acting Tuoning in the treatment of acute organophosphorus pesticide poisoning[J];Journal of Xi'an Jiaotong University(Medical Sciences);2006-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved