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《China Medical Herald》 2011-28
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Effect of intraperitoneal perfusion of Compound Matrine Injection combined with Cisplatin in the treatment of malignant ascites

HE Miao Department of Oncology,the People's Hospital of Wanzhou District,Chongqing 404000,China  
Objective: To observe the effect of intraperitoneal perfusion of Cisplatin combined with Compound Matrine Injection in malignant ascites.Methods: The treatment situation of 61 patients with malignant ascites which originated from gastrointestinal tumor in our hospital from April 2007 to April 2010 were analyzed retrospectively.And all the patients were randomly divided into two groups,31 patients in the treatment group(group A) were given intraperitoneal perfusion of Cisplatin combined with Compound Matrine Injection,30 patients of the control group(group B) were given intraperitoneal perfusion of Cisplatin only.Results: Total response rate was 57.3%.The response rate of group A showed significant difference compared with that of group B(64.5% vs 50.1%,P0.05).For the side effects,the occurrence of nausea,vomiting,marrow depression of group A were less than group B.The amount of white blood cells showed significant decrease after chemotherapy compared with baseline level in group B(P0.05),while no significant decrease was detected in group A(P0.05).Fewer side effects were detected in group A compared with group B.Conclusion: Intraperitoneal perfusion of Compound Matrine injection combined with Cisplatin can be used as a preferential palliative treatment method for clinical practices.
【CateGory Index】: R730.5
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