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《China Medical Herald》 2016-21
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Relationship between serum free β-HCG or AFP levels and obstetric complications in pregnant women

DING Haiying;ZHAO Yingmei;ZHU Pinhua;YANG Xiaoning;GAO Yi;SUN Huanmei;ZHANG Rui;Department of Gynaecology and Obstetrics,Pudong Hospital of Shanghai;Department of Dermatology,Pudong Hospital of Shanghai;Department of Gynaecology and Obstetrics,Pudong New Area Maternal and Child Health Care Center of Shanghai;  
Objective To study the relationship between serum free β-HCG,AFP in mid trimester of pregnancy and obstetric complications.Methods 135 pregnant women implemented with antenatal examination in Pudong Hospital of Shanghai from June 2014 to June 2015 were selected as research object.The levels of serum free β-HCG and AFP were monitored.And all of pregnant woman were divided into high β-HCG group(2 Mo M,18 cases),low β-HCGgroup( 0.5 Mo M,34 cases) and normal β-HCG group(0.5-2 Mo M,83 cases) according to the level of β-HCG.Otherwise,they were also divided into high AFP group(34 U/m L,24 cases),low AFP group(26 U/m L,35 cases) and normal AFP group(26-34 U/m L,76 cases) according to the level of AFP.The occurrence of obstetric complications of pregnant woman with different levels of β-HCG or AFP was analyzed.Results The incidence of gestational diabetes mellitus,gestational period hypertension,amniotic fluid and neonatal asphyxia in high β-HCG and AFP group were significantly higher than those of the pregnant woman in the normal β-HCG and AFP group(P 0.05).Difference of the incidence of gestational diabetes mellitus,gestational period hypertension,premature birth,oligoamnios,asphyxia neonatorum,miscarriage and placenta previa between the low β-HCG and the AFP group and normal group was not significantly(P 0.05).The incidence of gestational diabetes mellitus,oligoamnios and neonatal asphyxia in the high AFP and β-HCG group was significantly higher than that of the low β-HCG and AFP group(P 0.05).Conclusion The increase of serum free β-HCG or AFP can increase the incidence of obstetrics complication such as gestational diabetes mellitus and gestational period hypertension.
【CateGory Index】: R714.2
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