Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Herald of Medicine》 2005-07
Add to Favorite Get Latest Update

Inhibitory Effects of Cyclooxygenase-2 Inhibitory Drugs on Human Osteosarcoma and Lung Cancer Cell Lines

SUN Jing-hua,CAI Lin, CHEN Fang-zhou( Department of Orthopaedics,Zhongnan Hospital,Wuhan University,Wuhan 430071, China )  
Objective To compare the effects of two cyclooxygenase-2 inhibitors,celecoxib and rofecoxib on the growth of human osteosarcoma (HOS-8603) and lung cancer cell (A-549) lines. Methods The anti-proliferation effects were determined by methabenzthiazuron (MTT) method. The cell growing cycle and the cell apoptosis were analyzed by flow cytometry. Results Cyclooxygenase-2 inhibitors, celecoxib and rofecoxib had inhibitory and apoptosis-inducting effect on the growth of the two tumor cell lines. The inhibitions of celecoxib and rofecoxib to the two tumor cell lines were dose-dependent and time-dependent. The cells treated with the two drugs showed a G_2/M arrest which was the peak time of apoptosis. There was a significant difference between rofecoxib and celecoxib groups ( P 0.05). And celecoxib had a stronger inhibition to HOS-8603 than rofecoxib. Conclusion Cyclooxygenase-2 inhibitors, celecoxib and rofecoxib have significant effect on the growth of the two tumor cell lines, and may become useful medicines in tumor treatment.
【Fund】: 湖北省科技攻关计划基金资助课题(基金编号:2004AA304B08)
【CateGory Index】: R734.2;R738.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Ji Qing Li,Zhen Wang,Zheng Guo,Feng Guo,Zhi Yuan,Fu Cheng Ma,Pei Song Yan Ji Qing Li1,Zhen Wang1,Zheng Guo1,Feng Guo1,Zhi Yuan1,Fu Cheng Ma2,Pei Song Yan2,1Institute of Orthopaedics of PLA,2Department of Pathology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Rpovince,China;Relationship between the protein expressions of cyclooxygenase-2 and matrix metalloproteinase-7 in high risk osteosarcoma and the related factor of prognosis such as age,gender,onset time[J];Chinese Journal of Clinical Rehabilitation;2004-08
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Sun Jinghua,Cai Lin,Chen Fangzhou,et alDept.of Orthopaedics,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Inhibitory Effects of Cyclooxygenase-2 Specific Inhibitor on Human Osteosarcoma and Breast Cancer Cell Line[J];Journal of Hubei Medical University;2005-06
2 Tao Huang,Gang Lü,Da Xin Gao,Mao Wei Yang,Yan Feng Wang Tao Huang,Gang Lü,Da Xin Gao,Mao Wei Yang,Yan Feng Wang, Department of Orthopaedics,First Affiliated Hospital,China Medical University,Shenyang 110001,Liaoning Province,China;Significance of Fas and bcl 2 expressions on the occurrence and prognosis of osteosarcoma[J];Chinese Journal of Clinical Rehabilitation;2004-29
3 Chun Mei Wang1,Xiao Bo Bu1,Jie Song1,Yan Long Han1,Ying Wang1, Kai Dong1,Jing Li2,Yu Mei Wang2,Jian Bo Yu2,De Wu Dong2, 1Department of Biology,2Department of Pathology,Mudanjiang Medical College, Mudanjiang 157011,Heilongjiang Province, hina;Related factors of occurrence and metastasis of colon carcinoma and RAB5A gene[J];Chinese Journal of Clinical Rehabilitation;2004-32
4 Tao Huang,Gang Lü,Da-Xin Gao,Mao-Wei Yang,Yan-Feng Wang Tao Huang,Gang Lü,Da-Xin Gao,Mao-Wei Yang,Yan-Feng Wang,Department of Orthopedics,First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China;Expression and function of Caspase-3 and Fas in the occurrence and development of osteosarcoma[J];Chinese Journal of Clinical Rehabilitation;2004-35
5 Huang Tao,LüGang,Gao Da xin, Yang Mao wei,Wang Yan feng Huang Tao,LüGang,Gao Da xin, Yang Mao wei,Wang Yan feng,Department of Orth opaedics,First Affiliated Hospital,China Medical University,Shenyang 110001,Liao ning Province,China;Expression of PTEN and P53 in osteosarcoma and their effect on prognosis[J];Chinese Journal of Clinical Rehabilitation;2005-02
6 Bu Xiao bo1,Wang Chun mei1,Song Jie1,Han Yan long1,Wang Ying1,Li Jing2,Wang Yu mei2,Yu Jian bo2,Dong De wu2,1Department of Biology,2Department of Pathology,Mudanjian Medical College,Mudanjian 157011,Heilongjiang Province,China;Correlation of development,metastasis and prognosis of breast carcinoma with expression of RAB5A gene[J];Chinese Journal of Clinical Rehabilitation;2005-10
7 GENG Yan-hua1,WAN Chang-xing2,CHEN Pei-hui1(1.Department of Pathology,Second Affiliated Hospital,Zhejiang University Medical College,Hangzhou 310009,China;2.Department of Orthopaedics,Xinhua Hospital of Zhejiang Province,Hangzhou 310005,China);Expressions of Cox-2 and HIF-1α and their relationship with clinicopathologic characteristics of osteosarcoma[J];Tumor;2008-05
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 OUYANG Zhen,WANG Shuanke,KANG Xuewen,et al. Researsh Institute of Orthopedics,No.2 Hospital,Lanzhou University,Lanzhou 730000;Expression of cyclooxypenase-2mRNA,CD105mRNA,and the relation between cyclooxypenase-2mRNA and CD105mRNA in osteosarcoma[J];Chinese Journal of Bone Tumor and Bone Disease;2007-04
2 WANG Xianbin,SU Liguo,ZHANG Xiaojun,et al.Department of Orthopaedics,The Second Hospital of Handan,Hebei,Handan 056001;The correlation between the expression of cyclooxygenase-2 in osteosarcoma and lung metastases[J];Hebei Medical Journal;2009-01
3 ZHAN Xue-qin,CAI Wei-dong.Pediatric Department of the Songgang People's Hospital of Shenzhen,Shenzhen Guangdong 518105,China.;Significance of expression of Cox-2 and Fas in cases of osteosarcoma[J];Journal of Clinical and Experimental Medicine;2008-06
4 LIANG Xin- jun,XIA Ren- yun,YU Meng.Department of Orthopaedics.Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Express and significance of survivin and Cox- 2 in osteosarcoma[J];The Journal of Practical Medicine;2005-19
5 LIU Yao-ming,ZHOU Min-hui,ZHANG Da-fu,et al.(Department of Orthopaedics,Branch of Anning,Lanzhou General Hospital,Lanzhou Command,Lanzhou 730070,China);Expressions and clinicopathologic significance of MMP-7 and COX-2 in osteosarcoma[J];Medical Journal of National Defending Forces in Northwest China;2009-04
6 WANG Xian-bin,HU Wen-hai,LI Hui-jie,et al.The Osteonosus Department,the Third Affiliated Hospital of Hebei Medical University,Shijiazhuang,Hebei 050051,China;Expressions and clinical significances of cyclooxygenase-2,p53 in osteosarcoma[J];Orthopedic Journal of China;2007-23
7 ZHANG Pei-gen,WANG Shuan-ke,KANG Xue-wen,et al.Institute of Orthopedics,No.2 Hospital,Lanzhou University,Lanzhou 730030,China;Antiangiogenesis effect of celecoxib on xenografted human osteosarcoma stem-like cells in nude mice[J];Orthopedic Journal of China;2009-01
8 JIANG Bing,et al (Department of Respiratory Medicine,Yongchuan Hospital,Chongqing Medical University);Study of mechanism of action of specific inhibitor of COX-2 on Egr-1[J];Journal of Chongqing Medical University;2010-12
9 GENG Yan-hua1,WAN Chang-xing2,CHEN Pei-hui1(1.Department of Pathology,Second Affiliated Hospital,Zhejiang University Medical College,Hangzhou 310009,China;2.Department of Orthopaedics,Xinhua Hospital of Zhejiang Province,Hangzhou 310005,China);Expressions of Cox-2 and HIF-1α and their relationship with clinicopathologic characteristics of osteosarcoma[J];Tumor;2008-05
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 WANG Zhen 1, HUANG Yao Tian 1, HUANG Lu Yu 1, ZHAO Jin Kang 1, YU Hui Dong 1, LIU Ji Zhong 1, DU Xiao Chuan 2, LI Jing Bang 2, YAN Pei Song 3, WANG Zhi Xiang 4 1Institute of Orthopeadics of Chinese PLA, 2Department of Radi;Characteristics of high-risk osteosarcoma and treatment countermeasure[J];Journal of The Fourth Military Medical University;2002-05
2 Wang Xiangru,Qian Jixian,Long Hua,Fan Degang,Wen Yanhua,Fan Qingyu,Orthopedic Oncology Institute of Chinese PLA,Tangdu Hospital,Fourth Military Medical University,Xi ' an 710038,Shaanxi Province,China;Expression of oncogene correlates with survival rate and survival quality in osteosarcma[J];Modern Rehabilitation;2003-08
3 Liao Bo,Ma Baoan,Zhang Huizhong,Long Hua,Zhang Peng,Fan Qingyu,Department of Orthopeadics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038,Shaanxi Province,ChinaChen Gang,Department of Hematology,Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004,Shaanxi Province, China;Construction and evaluation of cDNA library of osteosarcoma 9607 cells[J];Modern Rehabilitation;2003-14
4 ;胃癌及癌旁组织中 COX-2基因蛋白的表达[J];World Chinese Journal of Digestology;2000-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved