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《Herald of Medicine》 2006-09
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Leflunomide in the Treatment of 50 Cases of Rheumatoid Arthritis

FENG Hong-jiang~1,XU Xiao-jun~1,TIAN Zai-quan~2,DENG Chang-quan~1(1.Department of Pharmacy;2.Department of Medicine,the People's Hospital of Liaocheng City,Shandong Province,Liaocheng 252000)  
Objective To compare the effectiveness and safety of leflunomide(LEF)with those of methotrexate(MTX) in patients with active rheumatoid arthritis(RA). Methods Ninty-five patients were randomly assigned to receive LEF or MTX.The patients in the treatment group received LEF 20 mg·d~(-1),and those in the control group received MTX 15 mg week,totally 12 weeks as a course of treatment. Results The total effective rates of the treatment group and the control group were 90.0%(n=50)and 95.6%(n=45)respectively.There was no significant difference between the two groups in the effectiveness (P0.05).The adverse reaction rate was 14.0%(7 case) in the treatment group and 15.6%(7 case) in the control group with no significant difference between the two groups(P0.05).But the adverse reactions were more tolerable in treatment group than those in control group. Conclusion This study suggests that LEF is an effective drug with minor adverse reactions for active rheumatoid arthritis.
【CateGory Index】: R593.22
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【References】
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1 Wang Wei,Hong Qiubing,Li Qiang,Qin Bei(Department of Pharmacy,Wuhan General Hospital,Guangzhou Military Region,Wuhan,Hubei,China 430070);Preparation and Quality Control of Leflunomide Chitosan Gel[J];China Pharmaceuticals;2008-13
【Co-references】
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1 Ma Jiliang (Dept.of Rheumatology,Beijing Friendship Hospital,Beijing 100050);The efficacy and safety of leflunomide in the treatment of active rheumatoid arthritis compared to methotrexate[J];Beijing Medical Journal;2000-06
2 BAO Chunde,HUANG Wenqun,CHEN Shunle,et al.Ren ji Hospital affiliated to Shanghai Second Medical University,Shanghai 200001, China;Treatment of rheumatoid arthritis with leflunomide:a double blind,randomised control study[J];CHINESE JOURNAL OF RHEUMATOLOGY;2000-01
3 Jiang Lindi,Wang Jiyao,Mei Zhenwu,Ni Liqing.Department of Rheumatology,Zhongshan Hospital,Shanghai Medical University,Shanghai,200032.;CLINICAL EFFECTIVENESS OF METHOTREXATE TREATMENT IN RHEUMATOID ARTHRITIS PATIENTS:A RANDOMIZED CONTROLLED TRIAL[J];CHINESE JOURNAL OF RHEUMATOLOGY;1998-04
4 ZHANG Ling-ling, DING Chang-hai, LIANG Zhao - zhao, WEI Wei, XU Jian-hua, LI Xiang-pei, BAO Chun-de,XU Shu-yun ( Institute of Clinical Pharmacology, Anhui Medical University , Hefei 230032, China ; Accessorial Hospital of Anhui Medical University , Hefei 230022, China; Anhui Province Hospital, Hefei 230065, China ; Shanghai Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China);Randomized double - blind controlled clinical trial of leflunomide in the treatment of rheumatoid arthritis[J];The Chinese Journal of Clinical Pharmacology;2005-05
5 Jiang Lindi, Yu Qang, Mei Zhenwu (Department of rheumatology, Medical School of Fudan University, Zhongshan Hospital, Shanghai 200032);Efficacy in Active Rheumatoid Arthritis Treated by of Leflunomide in Comparison with Methotrexate: A Randomized and Controlled Trial[J];Clinical Medical Journal of China;2000-04
6 Jiang Lindi Yu Qang Mei Zhenwu (Zhongshan Hospital, Fudan University, Shanghai 200032);Efficacy in Active Rheumatoid Arthritis Treated by Leflunomide in Comparison with Methotrexate: A Randomized and Controlled Trial[J];Clinical Medical Journal of China;2001-02
7 LAO Zhi Ying, NI Li Qing, ZHANG Zhi Li, ZHOU Jia Ling, CHEN Li Hua, ZHANG Fang, LIU Da Dong, YANG Xiao Ling, ZHU Qi, ZHANG Zha Ming, SHEN Jie (Guanghua Hospital, SHANGHAI 200052, China);Leflunomide in treating rheumatoid arthritis: a double blind study[J];Chinese Journal of New Drugs and Clinical Remedies;2001-02
8 BAO Chun-de 1, CHEN Shun-le 1, LAO Zhi-ying 2, NI Li-qing 2, L*B Sui-feng 3, CHEN Jie 3, JIN Xia-huan 3, XIAO Fei 3 (1. Department of Rheumatology, Renji Hospital, SHANGHAI 200001, China; 2. Department of Rheumatology, Guanghua Hospital, SHANGHAI;Leflunomide for rheumatoid arthritis in phase Ⅱ clinical study[J];Chinese Journal of New Drugs and Clinical Remedies;2002-06
9 Shuai Zongwen, Liu Shuang, Sun Guihua et al (Dept of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022);The phase Ⅱ clinical trial of leflunomide in treatment of rheumatoid arthritis[J];Acta Universitis Medicinalis Nahui;2002-01
10 LI Xiang Pei LI Xiao Mei WANG Guo Sheng SHAN Shu Guang QIAN Long (Department of Rheumatology, Anhui Provincial Hospital, Hefei, 230001);Clinical study of leflunomide in the treatment of patients with active rheumatoid arthritis[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2001-02
【Secondary References】
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1 SU Ran1,WEI Li1,CHEN Yan-chun2,LIU Yu3 1.Department of Rheumatism,the First A liated Hospital of Xinjiang Medical University,Urumuqi 830054,China;2.Department of Cadre,the First A liated Hospital of Xinjiang Medical University,Urumqi 830054,China;3.Evidence-based Medicine Center,the First A liated Hospital of Xinjiang Medical University,Urumuqi 830054,China;Efficacy and Safety of Leflunomide and Methotrexate in Treating Rheumatoid Arthritis:A Meta-analysis[J];Chinese Journal of Evidence-Based Medicine;2011-09
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