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《Herald of Medicine》 2010-07
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Anti-aging Effects of Skin Care Emulsion Mixed with Chinese Herbal Extracts

GAO Rui-ying1,2,ZHANG Xiu-yu1,2,MU Dan1,FU Zhong1(1.Department of Cosmetic Science,Guangdong Food and Drug Vocational College,Guangzhou 510520,China;2.Guangdong Research Institute of Traditional Chinese Medicine,Guangzhou 510520,China)  
Objective To study the anti-aging effects of skin care emulsion mixed with five kinds of Chinese herbal extracts(CHE). Methods Sixty female mice of 12 months were randomly divided into 3 groups(n=20): normal aging control group(N),low dose(L) and high dose(H) of CHE groups.Twenty other female mice of 3 months were used as young control groups(Y group).Skin care emulsion with 4% CHE was besmeared on the skin of mice in L group,that with 16% CHE was besmeared on H group,and cosmetic matrix without CHE was besmeared on N and Y groups for 60 d.The dorsal skin samples were collected to determine the contents of hydroxyproline(HYP),superoxide dismutase(SOD),malondialdehyde(MDA) and lipofuscin(LF). Results The SOD activity of natural aging group(N group) decreased more significantly,and the contents of MDA and LF increased obviously than those in the Y group,which showed that the natural aging model was successfully set up.The content of HYP in L and H groups reached to(30.85±3.71) and(35.46±3.54) mg·g-1,SOD were(17.92±0.58) and(20.38±0.71) U·mL-1,MDA were(6.92±1.38) and(5.96±1.25) mmol·g-1,LF were(6.13±1.73) and(4.89±1.15) μg·g-1,respectively,which were significantly different from those of the control group(P0.05). Conclusion The skin care emulsion with five CHE including angelicae sinensis has a noticeable anti-skin aging effect.
【Fund】: 广东省中医药局项目(基金编号:2009277);; 广药职院院级项目(基金编号:2006018 2008Z011)
【CateGory Index】: R285.5
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