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《China Pharmaceuticals》 2006-10
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Pharmacokinetics of a Single Dose of Oral Gatifloxacin in Beagle Dogs

Li Xuchun1,Zhu Hong2(1.Mianyang Central Hospital of Sichuan Province,Mianyang,Sichuan,China 621000;2.Department of Equipment,the First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing,China 400016)  
Objective To study the pharmacokinetics of a single dose of oral gatifloxacin capsules in Beagle dogs.Methods 18 Beagle dogs were divided into 34,17,8.5 mg/kg groups,single dose of 34,17,8.5 mg/kg of gatifloxacin was administrated.The blood samples were taken at 0.5,1,2,4,6,8,12,24,36,48,60 h after oral administration.The concentration of gatifloxacin in serum was determined by a HPLC method,pharmacokinetic parameters were calculated with pharmacokinetic program(3P97).Results The concentration-time curves of gatifloxacin fitted to one-compartment model.t1/2ka was(0.82± 0.96),(0.78± 0.77),(1.33± 0.43)h respectively,t1/2ke was(7.33± 1.79),(6.32± 3.28),(5.34± 2.60)h respectively,tmax was(6.32± 2.32),(3.95± 2.18),(5.77± 1.62)h respectively,Cmax was(6.31± 2.66),(2.67± 0.64),(0.64± 0.30)mg/mL respectively,AUC0→ 60 was(110.86± 43.76),(41.93± 5.58),(8.58± 2.70)μ g· h/mL respectively.Conclusion The gatifloxacin was absorbed rapidly,and high in plasma,and metabolized slowly.The convenience is oral administration gatifloxacin in clinical practice.
【CateGory Index】: R96
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