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《China Pharmaceuticals》 2008-07
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Effects of Puerarin on Insulin Sensitivity,Blood Glucose and Lipid in Metabolic Syndrome-type 2 Diabetic Rats

Tao Shugao1,Pan Jingqiang2,Kuang Shaosong3,Pan Tianmei3,Xiao Liuying2,Tan Hairong2 (1.Guangzhou First Municipal People's Hospital,Guangzhou,Guangdong,China 510180; 2.Guangzhou Institute of Traditional Chinese Medicine &Materia Medica,Guangzhou,Guangdong,China 510130; 3.Guangdong Provincial Medical Laboratory Animal Center,Guangzhou,Guangdong,China 510180)  
Objective To investigate the effects of puerarin on insulin sensibility and oxidative stress-free radical injure in metabolic syndrome-type 2 diabetic rats (MS-T2DM).Methods The model with lower dosage of streptozocin (25-30 mg/(kg·d),intraperitoneally injected,q.d.,1 d)and high caloric diet (abounded with sugar and fat) fed for 42 d,and the model of MS-T2DM with insulin resistance were performed;the effects of puerarin (0.3 g/kg,0.15 g/kg intragastrointestinally treated,q.d.,28 d)on the levels of fasting blood glucose (FPG),2 h blood glucose (2 h PG) after oral glucose tolerance test (OGTT) in vivo,and serum levels of total cholesterols (TC),low density lipoprotein-cholesterol (LDL-C),high density lipoprotein-cholesterol (HDL-C),triacylglycerol (TG),free fatty acid (FFA) fructosamine (FRA),Glycosylated hemoglobin (GHb),fasting insulin (Fins),malondialdehyde (MDA),insulin resistant index (IRI) and insulin sensitivity index (ISI),the activity of superoxide dismutase (SOD) in MS-T2DM with impaired glucose tolerance (IGT) were studied.Results Puerarin reduced the levels of FPG and 2 h PG after OGTT (P 0.01) and improved IGT in MS-T2DM,and the contents of MDA,TC,LDL-C,HDL-C,TG,FFA,Fins were lowered (P 0.01) and IRI was very significantly decreased (P 0.01),ISI was enhanced (P 0.01) and the activity of SOD was heightened (P 0.01),compared with the models of MS-T2DM.Conclusion Puerarin can lower hyperinsulinemia,ameliorate insulin sensibility,reduce blood glucose and lipids,and which mechanism is similar to the kind of metformin,and potentiates the effect of antioxidation in MS-T2DM.
【Fund】: 广东省中医药局滚动资助项目 项目编号:301005 302003
【CateGory Index】: R285.5
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