Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《China Pharmaceuticals》 2008-21
Add to Favorite Get Latest Update

Experimental Study of Effects of Curcumin Solid Dispersion Preparation on Fatty Liver in Rats

Zhang Yu,Huang Xiuwang,Xu Jianhua,Wen Caixia(Institute of Clinical Pharmacology,Fujian Medical University,Fuzhou,Fujian,China 350004)  
Objective To observe the preventing effect of Curcumin Solid Dispersion Preparation on fatty liver in rats.Methods Sixty mice were randomly divided into six groups,such as normal group,model group and three curcumin groups in different doses.The compound fatty liver models were induced by high-fat feeding,intragastric administration with the alcohol and subcutaneous injection with CCl4.On 16 d, all the mice were killed,and the contents of TG,CHO and LDL-C in the serum and the liver tissue were determined.The change of liver histology was observed.Results The contents of TG,CHO and LDL-C in the serum and the liver were decreased in the curcumin-treating groups compared with the model group.The liver histology and liver indexes of the curcumin-treating groups were better than those of the model group.Conclusion Curcumin can prevent fatty liver,and the effect may depend on its dose.
【Fund】: 福建省产业技术开发项目资助 项目编号:闽发改高技[2004]686号。
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 YU Qin;CAO Li;HUANG Hai-qin;Jiangyan Hospital of Traditional Chinese Medicine;;Hua-Zhuo-Jie-Du-Hu-Gan Decoction Treatment on 30 Cases of Fatty Liver[J];Journal of Chengdu University of Traditional Chinese Medicine;2013-03
2 XU Fan1,YE Yuan-tu1,CAI Chun-fang1,ZHANG Bao-tong2,XIAO Pei-zhen2,WANG Li-hong2, XIANG Chao-lin1,YAO Lin-jie1,LIU Meng1,LI Wei3(1.College of Basic Medical and Biological Sciences of Soochow University,Key Laboratory of Aquatic Animal Nutrition in Jiangsu,Suzhou 215123,China 2.Beijing Institute of Nutrition Source,System Engineering Research Center for Nutrition,Beijing 100069,China 3.School of Life Science of Zhongshan University,Guangzhou 510275,China);Effects of yeast culture,curcumin and silymarino on lipid metabolismrelated genes expression activity of liver injured by thioacetamide in grass carp[J];Journal of Fisheries of China;2012-05
3 MAI Jing-yin1 PING Jian1,2 LIU Yu-li1,2 CHENG Yang1,2 CHEN Gao-feng1,2 WANG Mei-feng1,2 ZHOU Yang1,2 1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine 2.Shanghai University of Traditional Chinese Medicine;Differential Proteomics Analysis of Curcumin for Non-alcoholic Fatty Liver Disease in Rats[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2012-05
Chinese Journal Full-text Database 4 Hits
1 Wo xingde; Gao Chenxian;Hong xingqiu et al(Institution of Molecular Medicine, Zhejiang College of TCM, Hangzhou 310009);Experimental Study about the Extracts of Turmerol in Dietary Rabbit with Hyperlipemia[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;1999-01
2 Pan Zhimin, Li Yuhua, Huang Qi, et al Hospital Affiliated to Zhejiang College of TCM, Hangzhou ( 310006);Experinental study of TiaoZbiJi Soluble Granules on Fatty Degeneration of Liver in Mices[J];Journal of Zhejiang College of Tcm;2003-06
3 LI Wenbiao, WANG Yiren. Department of Liver Disease, Shanxi Chinese Medical and Herbal Institute (Taiyuan, 030012);Experimental Study on Treatment of Fatty Liver with Hyperlipemia by Qingyuan Tiaozhi (QYTZ) Capsule[J];Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases;2001-03
4 WANG Xiaojun,ZHANG Xiaogang,ZHANG Xuewen,et alDoctor of Grade 2002,Guangzhou University of TCM, Guangzhou 510405;Experimental Study on the Effect of Qinggan Huoxue Decoction on Resisting Fatty Liver Rats[J];Chinese Journal of Integrated Traditional and Western Medicine On Gastro-spleen;2003-02
Chinese Journal Full-text Database 10 Hits
1 Zhao Geping; Wo Xingde; Jin Mingmin; et al (Institution of Molecular Medicine, Zhejiang College of TCM, Hangzhou 310009);Turmerol Extract's Inhibition on Oxidative Modification and Low Density Lipoprotein (LP) in Cells Cultured in Vitro[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;1999-03
2 Hong Xingqiu; Huang Yan fen; Yan Jianwei et al(Molecular Institution of Zhejiang College of TCM, Hangzhou(310009) (Central Laboratory of Zhejiang College of TCM);Component Analysis of the Region in Turmerol's Reducing Blood-lipid[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;1999-06
3 Wei Xiujun,Wang Zhuwen,Xu Xinsheng (Peoples Hospital of Dongying,Dongying 257091);A CLINICAL STUDY OF FATTY LIVER IN MIDDLE-AGED PATIENTS[J];Journal of Binzhou Medical College;2001-05
4 Yu Yong-jun,Liu Qing-xin,Qi Xiu-ling,et al. (Cangzhou Medical College,Hebei Province,Cangzhou 061001China);Experimental Study of QuZhiBaoGan Ranules on the Fat Metabolism of Rat's Fatty Liver that Were Reduced by High Fat Diet[J];Chinese Journal of Medicinal Guide;2010-09
5 Luo Zhao-li,Li Rong,Shi Wen-hui,et al. (Beijing Military sanatorium of Beidaihe of Department of pharmacy,Qinhuangdao 06610,China);Homemade" Qingyuan Tiaozhi capsule" Mechanism Research[J];Chinese Journal of Medicinal Guide;2011-11
6 PAN Xue-feng1,2,WEN Cai-xia1,XU Jian-hua1 (1.Institute of Clinical Pharmacology,School of Pharmacy,Fujian Medical University,Fuzhou,Fujian 350004,China;2.Department of Pharmacy,Fujian Health College,Fuzhou,Fujian 350101,China);Comparison of two cell lines for cell model of hepatocytic steatosis in vitro[J];Journal of Guangdong Pharmaceutical College;2010-01
7 PAN Xue-feng1,2,WEN Cai-xia1,XU Jian-hua1 (1.Institute of Clinical Pharmacology,School of Pharmacy,Fujian Medical University,Fuzhou,Fujian,350004;2.Department of Pharmacy,Fujian Heath College,Fuzhou,Fujian,350101,China);Experimental study of effects of tetrahydrocurcumin on fatty liver[J];Journal of Guangdong Pharmaceutical College;2010-06
8 ZHANG You-ding, et al.;Study on risk factors related to island residenter's fatty liver in Zhoushan[J];Chinese Journal of Public Health Management;2005-03
9 ZHANG Zhi-zhe,QING Yao,WU Hui-hong,ZHANG Xi-yuan,LU Gui-qing,HE Wen-jun,YANG Li-yan(Affiliated Nanning First People's Hospital of Guangxi Medical University,Nanning 530022,China);Prevalence of Fatty Liver and its Risk Factors in General Adult Population of Nanning Urban District[J];Guangxi Medical Journal;2011-11
10 FENG Jun1,WANG Wen-min2,LI Yu-ming1 (1.University Hospital of Kunming Medical University,Kunming 650031,China; 2.First Affiliated Hospital of Kunming Medical University,Kunming 650032,China);Analysis on Current Situation of Chronic Disease in University Teachers and Staff Members[J];Health Medicine Research and Practice;2013-02
Chinese Journal Full-text Database 10 Hits
1 YE Bao-hua,WANG Zhi-ming,ZHONG Wei-hua,LU Bing,CHEN Ming-yuan(Zhenjiang Health School,Zhenjiang Jiangsu 212004);Protective and therapeutic effects of andrographolide on nonalcoholic steatohepatitis[J];Anhui Medical and Pharmaceutical Journal;2008-07
2 Wo Xingde,Hong Xingqiu,Gao Chengxian,et al Molecular Medical Institution,Zhejiang College of TCM,Hangzhou(310009);Long-period Virulent Test of Curcumin[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-01
3 Wo XingdeHong XingqiuGao Chengxian Molecular Medical Institution,Zhejiang College of TCM,Hangzhou(310009);Maximum Toleration Test of Curcumin[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-02
4 HE Shan LIANG Xu-Fang LIAO Wan-Qin YAO Wei LI Guang-Zhao ZHU Wei-Feng(College of Life Science and Technology,Jinan University,Guangzhou 510632,China);Molecular Cloning and Tissue Expression of Glutathione Peroxidase cDNA in Hypophthalmichthys molitrix,Aristichthys nobilis and Ctenopharyngodon idella[J];Chinese Journal of Zoology;2007-03
5 Zhang Zhihong Xu Limin Yao Baoqiang Department of Chemical Engineering ,Beijing Institute of Petro-chemical Technology,Beijing 102617;Spectrophotometry Determination of Raspberry Ketone[J];Journal of Beijing Institufe of Petrochemical Technology;2005-04
6 LIU Shu-jun, HUANG Jing-juan (Director CHE Nian-cong) (College of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100069, China);Experimental study on effect of Erchen decoction and Taohongsiwu decoction on CYP2E1 activities in non-alcoholic fatty liver rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-08
7 SHU Dan1,ZHENG Ren-yuan,YE Xiao-jin3,LUO Qin3,ZHANG Tao2(Chengdu Medical College,1.Grade 2003 in department of Clinical Medicine,2.Department of Bio-chemistry;3.Grade 2006 in department of Biotechnology,Chengdu 610083,China);A Study on Extraction and Determination of Capsaicinoid[J];Journal of Chengdu Medical College;2007-02
8 LIU Cun-qi,WANG Wei-wei,ZHANG Ya-juan(Department of Life Science,Hebei University,Baoding 071002,China);Advance on Superoxide Dismutase in Aquatic Organisms[J];Fisheries Science;2005-11
9 LIU Hua-jie,LIU Song(College of Chemistry,South China University of Technology,Guangzhou 510640,China);Stability of white oil W/O/W multiple emulsions[J];China Surfactant Detergent & Cosmetics;2007-02
10 BAI Mei,REN Meng-jun,LIU Zhong-he△(Department of Gastroenterology,Qianjiang Central Hospital of Chongqing,Chongqing 409000,China);Clinical observation on berberine treating non-alcoholic fatty liver disease[J];Chongqing Medicine;2009-10
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 DONG Shu1,2,LIU Ping1,2,3,SUN Mingyu1,2,3(1.Key Laboratory of Liver and Kidney Diseases,Institute of Liver Diseases,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;2.Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China;3.E-institute of Shanghai Municipal Education Commission,Shanghai 201203,China);The Development of Treatment for NAFLD[J];Liaoning Journal of Traditional Chinese Medicine;2013-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Fan Jian - gao; Ang Ming - de; li ji - qtang, et al. (Shanghai institute of digestive disease, Renji hospital, Shanghai 2nd medical uniwnity, Shanghai 200001);Andysis of Risk Factors of Fatty Iiver and Social bovention[J];SHANGHAI JOURNAL OF PREVENTIVE MEDICINE;1998-01
2 Fan Jiangao,Chen Lianghua,Zeng Mingde,et al.Depatment of Diges search for tive Disease. Shanghai first people's hospital. Instotutu of Digestive Discaas Shanghai(200080 and 200001),China.;Effects of pravastatin,Vitamin E and Captopril on the development of hyperlipidemia,atherosclerosis and fatty liver in rabbits chronically fed with high fat diet[J];SHANGHAI MEDICAL JOURNAL;1998-12
3 FAN Jian Gao 1, ZENG Min De 2, HONG Jian 3, LI Ji Qiang 2 and QIU De Kai 2 1Shanghai First People's Hospital, Shanghai 200080, China 2Shanghai Institute of Digestive Diseases, Shanghai 200001, China 3Shanghai Institute of;Effects of free unsaturated fatty acids on proliferation of L 02 and HLF cell lines and synthesis of extracellular matrix[J];;1998-06
4 Zhao Xiaoxian , Yan Yichai , Fu Xiaosuo , et al Dept . of Physiology. , Beijing.Medical Staff College;Effect of Exercise Treatment on Fatty Liver in Diet - induced Hypercholesterolemia Rats[J];CHINESE JOURANAL OF SPORTS MEDICINE;1997-03
6 Fan Jiangao , Zeng Mingde, Hong Jian, et al.; Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Second Medical University, Shanghai, 200001 [;Effects of TG,VLDL,OX-VLDL on proliferation of L-02 and HLF cell lines and synthesis of extracellular matrix[J];CHINESE JOURNAL OF DIGESTION;1998-02
7 Fan Jiangao, Zeng Minde, Li Jiqiang, et al. Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001;CORRELATION BETWEEN HEPATIC FAT, LIPID PEROXIDATION AND HEPATIC FIBROSIS IN RATS CHRONICALLY FED WITH ETHANOL AND/OR HIGH FAT DIET[J];CHINESE JOURNAL OF INTERNAL MEDICINE;1997-12
8 LU Lungen, ZENG Minde, FAN Jiangao, et al. Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Second Medical University, Shanghai 200001;Intercellular adhesion molecule 1 expression in experimental liver fibrosis[J];CHINESE JOURNAL OF INTERNAL MEDICINE;1999-01
9 Department of Pharmacology; He Gaoqin, Xue Chunsheng;STUDIES ON THE MYOCARDIAL ANTIISCHEMIC ACTION AND THE TOXICITY OF CURCUMA LONGA RHIZOME[J];Journal of Chongqing Medical University;1986-01
10 Huang Zhaosheng, Wang Zongwei, Huang Zhenyan, Zhong Shiqing, Li Qiaomei, Xu Qin Guangzhou University of TCM (Guangzhou, 510407);Histopathology and Ultrastructure Evaluation on Hujin Pills on Antisteatosis of Rat Liver[J];Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases;1998-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved