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《China Pharmaceuticals》 2012-15
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Study on Hypolipidemic and Antioxidation Action of 50% Ethanol Fraction in Gynostemma Pentaphyllum

Chen Guilin,Le Zhiyong,Lu Kungang,Jiang Linjie,Fang Nianbai,Yu Shanggong(Key Laboratory of Chinese Medicine Resource and Compound Prescription of Ministry of Education,Hubei University of Chinese Medicine,Wuhan,Hubei,China 430065)  
Objective To study the effects of the 50%ethanol fraction from the extract of Gynostemma pentaphyllum(GP) on lipid-decreasing and antioxidant action in mice.Methods High-fat diet was used to make the hyperlipidemia mice model.The mice were divided into four groups:control,high fat diet(HFD),positive HFD control and 50%ethanol fraction treatment.The mice were treated with medication once a day for 30 d.Serum levels of TC,TG,HDL-C and malonaldehyde(MDA) were measured.Also,the activity of super oxidant dismutase(SOD) was determined.Results In comparison with HFD control group,the 50%ethanol fraction treatment group significantly reduced TC,TG,LDL-C,MDA and the arteriosclerosis index(AI),increased SOD,HDL-C/TC and HDL-C(P0.05 or P0.01).In addition to the liver coefficient(P0.05),no significant influences were seen in the renal index and spleen index(P0.05).Conclusion The 50%aqueous alcohol fraction in GP can decrease TC and MDA significantly with obvious anti hyperlipidemic and antioxidant action in mice.
【CateGory Index】: R285.5
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