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《China Pharmaceuticals》 2015-16
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Influence of Sevoflurane on Heme Oxygenase- 1 in Patients with One Lung Ventilation during Thoracic Surgical Procedures

Zhang Hongqin;Zheng Jing;Jiang Chunxiu;Zhang Jing;Chongqing Municipal Third People's Hospital;  
Objective To investigate the influence of sevoflurane on heme oxygenase- 1( HO- 1) in the patients with one lung ventilation( OLV) during thoracic surgical procedures. Methods Forty patients undergoing thoracic surgical procedures with OLV were selected and randomly divided into the total intravenous group( group P) and the sevoflurane whole course inhalation group( group S),20 cases in each group. The radial arterial blood was collected at the anesthesia induction( T0),before OLV( T1),at 30 min after the end of OLV( T2) and 24 h( T3). The bronchoalveolar lavage fluid was collected at T1 and T2. The chemical colorimetric method was adopted to detect the content or activity of malondialdehyde( MDA) and superoxide dismutase( SOD) in serum and bronchoalveolar lavage fluid. ELISA was adopted to detect the level of HO- 1 in serum and bronchoalveolar lavage fluid. Results The levels or activity of MDA,SOD and HO- 1 in serum at T2 and T3 in the group P were significantly higher those at T0 and T1( P 0. 05),while the MDA level in the group S was significantly decreased compared with the group P and SOD and HO- 1 levels were significantly increased( P 0. 05).The MDA,SOD and HO- 1 levels in bronchoalveolar lavage fluid at T2 in the group P were significantly higher than those at T1( P 0. 05),while the MDA level in the group S was significantly decreased compared with the group P,while the SOD and HO- 1levels were significantly increased( P 0. 05). Conclusion Sevoflurane can decrease the content of MDA in serum and bronchoalveolar lavage fluid in the patients with OLV,enhances the SOD activity,increases the HO- 1 level,possesses the effect for anti- oxidative stress injury,which could be realized by activating Nrf2 / ARE signal pathway and affecting HO- 1 expression.
【Fund】: 重庆市卫生局科研资助项目 项目编号:2012-2-217
【CateGory Index】: R614
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