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《China Pharmaceuticals》 2016-02
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Chronic Toxicity of Shenyan Capsules on Rats

Fan Zhiyun;Tan Huiping;Shandong Institute for Food and Drug Control;Jinan Third People's Hospital of Jinan;  
Objective To observe the chronic toxicity of Shenyan Capsule on rats.Methods Wistar rats were orally given Shenyan Capsule at dose of 1.5,0.5 g/kg(equal to 50 and 16.7 times of clinic dosage respectively),reated for 6 months and stopped for 1 month.The animal growth condition,indexes of hemotology and biochemistry,and the histopathology of the major organs were examined.Results The outer appearance and behavior,weights,organ coefficient,the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group.The pathological examination did not discover significant pathological changes related to drug toxicity and the delayed toxicity reaction after drug administration.Conclusion Shenyan Capsules have no significant toxicity for long — term administration on rats.It infers that the drawing — up doses in clinic will be safe.
【CateGory Index】: R285.1
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