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《China Pharmaceuticals》 2017-22
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Establishment of Near-Infrared Spectroscopy Qualitative Model for Benazepril Hydrochloride Tablets

Jin Peng;Liu Yan;Bu Yuanyuan;Huaian Institute for Food and Drug Control;  
Objective To establish a qualitative analysis model for Benazepril Hydrochloride Tablets.Methods Near-infrared diffuse reflectance spectrophotometry(NIRDRS) was adopted to collect near-infrared spectra(NIRS) of 61 batches of samples from 4 manufacturers,chemometrics spectral aanalysis software OPUS was adopted to establish the two-layer qualitative model and series confirmed model,and the accuracy and specificity of the model were verified.Results The model had good accuracy and specificity,it can accurately identify 21 batches of samples and distinguish 4 structural analogues,counterfeit A enterprise samples and 21 non-structural analogues.Conclusion The model established in this experiment can quickly and accurately identify the authenticity of Benazepri l Hydroch1 oride Tab1 ets,which is suitable for the spot rapid diagnosis of the drug on the drug testing vehicles.
【CateGory Index】: R927
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