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《China Pharmaceuticals》 2019-06
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Clinical Study on Zhigancao Decoction and Zhuling Decoction Combined with Furosemide in the Treatment of Hepatocirrhosis with Seroperitoneum

SUN Shaoke;WANG Lan;ZHAO Yuntao;Longyao County Hospital in Xingtai City;Nanhe County People's Hospital in Xingtai City;  
Objective To investigate the clinical effect of Zhigancao Decoction and Zhuling Decoction combined with furosemide in the treatment of hepatocirrhosis with seroperitoneum. Methods Totally 82 patients with hepatocirrhosis with seroperitoneum admitted to our hospital from September 2016 to January 2018 were selected and divided into the control group( n = 39) and the observation group( n =43) according to the random number table method. The patients in the two groups were given routine Western medicine treatment( including oral administration of furosemide), on this basis, the patients in the observation group were treated with modified Zhigancao Decoction and Zhuling Decoction. Results The total effective rate of the observation group was 83. 72%,which was significantly higher than 46. 15% of the control group( P 0. 05). Compared with before treatment,the blood indexes of the two groups were significantly improved after treatment( P 0. 05). The levels of alanine aminotransferase( ALT), aspartate aminotransferase( AST), blood urea nitrogen( BUN), serum creatinine( SCr), angiotensin Ⅱ( Ang Ⅱ) and aldosterone( Aldo) in the observation group were significantly lower than those in the control group( P 0. 05). Multivariate Cox proportional hazard model analysis showed that Ang Ⅱ and Aldol were independent factors influencing the clinical effect( P 0. 05). Conclusion Modified Zhigancao Decoction and Zhuling Decoction combined with furosemide can be used in the treatment of hepatocirrhosis with seroperitoneum, and it can improve liver function. Its mechanism is related to inhibiting the activation of the renin-angiotensin-aldosterone system( RAAS).
【Fund】: 河北省邢台市科技计划项目[2016ZC130]
【CateGory Index】: R575.2
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