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《Chinese Journal of Applied Chemistry》 2000-06
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On the Factors Influencing the Antibacterial Activity of Chitosan

YANG Dong-Zhi, LIU Xiao-Fei, LI Zhi, XU Huai-Yu, GUAN Yun-Lin.*, YAO Kang-De (School of Material,Tianjin University,Tianjin 300072)  
The effects of concentration, deacetylation degree, molecular weight and pH of medium on the antibacterial activity of chitosan against Esherichia Coli have been investigated. The results showed that the antibacterial activity of chitosan increased with increase in concentration and deacetylation degree and it first increased with increasing molecular weight, reached a maximum at M w=9.16×10.4 and pH=6.5 and then decreased with further increase in molecular weight. The effects of chitosan on the E.Coli was studied morphologically by confocal laser scanning microscopy and SEM with the results that the E.Coli cells were deformed and autolysed in contact with chitosan samples.
【Fund】: 国家自然科学基金资助项目!(5 97730 0 2 )
【CateGory Index】: O636
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