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《Practical Journal of Clinical Medicine》 2006-02
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Clinical evaluation for protein chip system of multi-tumor marker detection

FU Ben-qi,LIU Xian-hua,SHE Wei,et al.(Nuclear Medicine Department,Sichuan Provincial People's Hospital,Chengdu 610072,China)  
Objective To study the clinical value of protein chip system in the detection of multi-tumor markers(C-12 system).Methods The serums of 114 malignant tumour patients,32 benign disease patients and 52 healthy subjects were detected by C-12 system.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of C-12 system were analyzed.The results of C-12 system were compared with those of chemiluminescence immunoassay,DELFIA and IRMA,and the correlation between C-12 system and the others was evaluated.Results Among the 114 malignant tumour patients,106 were positive,while 19 were positive among 84 controls.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of C-12 system were 92.9%,77.4%,86.4%,84.8%,89.0%,respectively.There was significant positive correlation between the results of C-12 system and the others(r=0.494~0.895,P 0.001).Conclusion C-12 system is appropriate for clinical diagnosis and outcome prediction of tumours,particularly for tumour screening of healthy group.
【CateGory Index】: R730.4
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