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《Evaluation and Analysis of Drug-Use in Hospitals of China》 2008-09
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Effect of Danshen Freeze-drying Injectable Powder on Cerebral Microcirculation in Rats

LIU Ping~ 1 , CUI Xue-shun~2, HE Xin-rong~1, ZHAO Yue-feng~2, SHEN Ran-ran~1 (1.Dispensary of TCM, Drug Supply Center, PLA General Hospital, Beijing 100853, China; 2.Harbin Pharmaceutical Group Second Factory of TCM, Harbin 150076, China)  
OBJECTIVE:To the effect of Danshen freeze-drying injectable powder on cerebral microcirculation in rats and to enlarge the indication of this injection powder. METHODS: The rats were randomized divided into four groups: high, middle, low doses of Danshen freeze-drying injectable powder and control group. After Danshen freeze-drying injectable powder were injected for 14 days, craniotomy was performed on rats and the experimental microcirculation disturbance model was induced by injecting rats with giant molecule glucosan. The volume of blood flow and the blood viscosity of rats at 1, 8, 25, and 50min after administration of Danshen freeze-drying injectable powder were observed. RESULTS: The volume of blood flow was markedly increased in rats treated with either high dose or middle dose of Danshen freeze-drying injectable powder. Compared with the control group, the blood viscosity was significantly lowered in all the rats treated with Danshen freeze-drying injectable powder (high, middle and low doses) (P0.05). CONCLUSION: Danshen freeze-drying injectable powder is of importance in improving the cerebral microcirculation and lowering the blood viscosity in rats.
【CateGory Index】: R285
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