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《Evaluation and Analysis of Drug-Use in Hospitals of China》 2009-10
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Yanshu Injection Combined with PP Regimen for Patients with Advanced Non-Small Cell Lung Cancer:A Clinical Observation

ZHANG Ze-yu,YI Sheng-ming(Dept of Oncology,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China)  
OBJECTIVE: To observe the short-time efficacy and adverse effects of Yanshu Injection combined with PP regimen in the treatment of patients with advanced non-small cell lung cancer(NSCLC).METHODS: The patients in the control group were treated with chemotherapy with Paclitaxel(PTX) 150 mg·(m2)-1 by intravenous drip on day 1 plus Cisplatin(DDP) 25 mg·(m2)-1 by intravenous drip from day 1 to day 3,with efficacy evaluated after treatment for 2 cycles(one cycle defined as 21 days);the treatment group received the above chemotherapy plus Yanshu Injection(20 mL) by intravenous drip q.d for 14 days,with efficacy evaluated after treatment of 2 cycles.RESULTS: The total short-term effective rate was 42.59% in the treatment group vs.31.48% in the control group,showing no significant difference between the two groups(P0.05);however,the gastrointestinal reactions and the myelosuppression in the treatment group were alleviated as compared with the control group,and there were significant differences between the two groups(P0.05).CONCLUSION: Yanshu Injection plus PP regimen showed good efficacy but mild toxic reactions in patients with advanced NSCLC.
【CateGory Index】: R734.2
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