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《Evaluation and Analysis of Drug-Use in Hospitals of China》 2011-11
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Efficacy of Compound Kushen Injection plus Cisplatin for Advanced Gastrointestinal Malignant Ascites

LI Dong-hua*(No.7 Dept. of Internal Medicine,Dujiangyan Medical Center,Dujiangyan 611830,China)  
OBJECTIVE:To evaluate the curative efficacy of compound Kushen injection plus cisplatin for advanced gastrointestinal malignant ascites.METHODS: The enrolled patients were intraperitoneally injected with Kushen injection plus cisplatin(treatment group) or cisplatin alone(control group).The curative efficacy was compared between the two groups.RESULTS: In the treatment group,the effective rate for ascites was 77.3%(82/106),with gastrointestinal tract adverse reactions appearing in 28.3%(30/106),myelosuppression in 25.5%(27/106) and improvement in the quality of life in 68.9%(73/106),as compared with in effective rate for ascites in 45.0%(63/140),gastrointestinal tract adverse reactions in 42.1%(59/140),myelosuppression in 45.7%(64/140) and improvement in the quality of life in 44.3%(62/140) in the control group,showing significant differences between the treatment group and the control group.However,no significant differences were noted between the two groups regarding the incidences of abnormalities in creatinine,which indicated that it remains to be further studied about the efficacy of Compound Kushen Injection in reducing creatinine level.CONCLUSION: The regimen of compound Kushen injection in combination with chemotherapy in intraperitoneal chemotherapy was proved to be safe and effective with remarkable synergic effect yet milder adverse reactions meanwhile improving patients' quality of life thus it is an effective means for advanced gastrointestinal malignant ascites.
【CateGory Index】: R735
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