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《Guide of China Medicine》 2010-15
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The Influence of Cognitive Function in Parkinson’s Patients with Liu Wei Di Huang Wan

XUE Hong,GUO Zhou-ke (Department of Neurology,Shenzhen Hospital of TCM,Shenzhen 518033,China)  
Objective To evaluate the influence of Liu Wei Di Huang Wan on cognitive functions in PD patients already treated with levodopa. Methods The cognitive performance of 85 non-demented idiopathic Parkinson’s disease(PD)patients treated with levodopa alone or receiving Liu Wei Di Huang Wan as add-on therapy to levodopa was evaluated in the present study during 6 months of treatment.Neuropsychological tests were administered two times.Results In the first assessment to differentiate test sensitive to cognitive changes typical for PD normal group was also assessed.After 6 months of treatment PD patients were retested only with tests that differentiate them from normal group.Compared to normals PD patients showed inferior performance on Stroop Interference test,Trail Making test,letter fluency and Hooper Visual Organization Test.Trail Making test A and B are lower in Liu Wei Di Huang Wan group compared with those receiving levodopa only after 6 months(P0.05).No other statistically significant differences between two groups and first and second neuropsychological assessment were found,but there was a trend for a rise on letter fluency and in group additionally treated with Liu Wei Di Huang Wan.Conclusion Liu Wei Di Huang Wan as add-on therapy to levodopa shows beneficial influence on executive function in PD patients.It is safe in non-demented PD patients in terms of the effect on cognitive performance.
【CateGory Index】: R277.7
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Chinese Journal Full-text Database 1 Hits
1 Su Qiaozhen,Sun Yuzhi,Zeng Liang,Lian Xinfu(Fujian College of TCM,Fuzhou 350108,China);The Current State of Traditional Chinese Medicine in Treating Parkinson's Disease[J];Guangming Journal of Chinese Medicine;2008-04
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