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Clinical Report of 2205 cases of Rotating Gamma Knife Treatment of Intracranial Diseases

LIU Jing-pin,QIN Kun-ming,WANG Ren-sheng,HUANG Wei-qing,HUANG Li,LEI Hai-fang,WANG Min(Gamma Knife Surgery Department,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)  
Objective To evaluate the effects of gamma knife radiosurgery in intracranial diseases.Methods The 2-3mm slice thickness images were performed by GE 1.5T MRI scanners,and dosage planning was made using Super Plan 2.5/3.0 system,marginal does were ranged from 8 to 98Gy with isdose lines ranged from 35%-75%,the isocenters ranged from 1 to 13,treated with Masep new style rotating gamma knife.During March 2002 to October 2012,2783 patients with intracranial diseases were treated in our center,and 2205 patients,containing 1212 male and 993 female,integrated followed up were enrolled in the study.Results The following up duration was 3 months to 127 months(average 58.30 months) after γ-knife treatment.The effective rate of γ-knife treatment in different diseases was follows: benign tumors 88.57%(922/1041),malignant tumors 83.59%(494/591),cerebrovascular malformations 85.92%(360/419),functional diseases 85.06%(131/154).Five patients were performed craniotomy for cerebral edema decompression or recurrent tumor resection.And 12 patients were treated 2-5 times for the niduses too big or too more.Conclusion The treatment of rotating γ-knife radiosurgery in intracranical benign tumors,malignant tumors,artereovenous malformation and functional diseases is effective.Thus it is an important therapentic approach in neurosurgery.
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