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《Acta Nutrimenta Sinica》 1987-02
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INFLUENCE OF MANGANESE ON SELENIUM METABOLISM IN RATS

Meng Xianzhong, Yu Weihan, Zeng Shaojuan, Zhou Baochu and Kang Baoan(Institute of Keshan Disease, Harbin Medical University, Harbin)  
The effects of manganese on selenium content and glutathione peroxidaseactivity in blood and myocardium, and on selenium excretion in growing ratswere studied to ferret out the interaction of the two essential trace elements.Manganese dichloride (40mg/kg of MnCl2.4H2O) was administered daily to a group of 17 rats for 35 days intraperitoneally. An obvious increase in manganese content in serum and myocardium was induced. However, selenium levels in the two tissues of manganese-treated rats were significantly lower than the controls. From the 14th day on, glutathione peroxidase activities in whole blood of manganese-treated rats were below the controls, and on the 35th day, the activities of the selenium-containing enzyme in blood and myocardium were reduced by 29.33% (P0.001) and 20.48% (P0.001) respectively. Negative correlations between manganese and selenium and between manganese and glutathione peroxidase in the two tissues were found.75Se-selenite was given orally to another group of 6 rats after treatment with manganese for 7 days, and a higher level of 75Se in urine was observed during the slow phase of excretion.In conclusion, excessive exposufe to manganese increases selenium excretion,thereby depleting tissue stores of selenium and the activities of selenium-containing enzyme.
【Key Words】： manganese selenium glutathione peroxidase
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