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《Acta Nutrimenta Sinica》 2004-05
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YANG Xiao-quan, ZHANG Hai-de, LI Ling ( College of Food and Bioengineering,, South China University of Technology, Guangzhou 510640, China)  
Objective: To study the antioxidative and antilipemic effect of the flavonoids purified from pomelo (Citrus grandis L.Osbeck) peel. Methods: The flavonoids were isolated and purified by NKA-12 macroporous adsorption resin and the polyamide column chromatography, and preparative TLC and HPLC. DPPH radical scavenging potential and inhibition of human LDL oxidation in vitro were determined. The effects TG , TC, HDL-C and LDL-C were investigated in mice with hypercholesterolemia induced by egg yolk. Results: Three kinds of flavonoids antioxidants named P11, P12 and P2, deduced as hesperidin, naringin and eriocitrin, were purified from pomelo peel. The radical scavenging potential of P2, P11 and P12 were 52.5%, 37.8% and 39.0% respectively (P0.05). The inhibition ability of human LDL oxidation expressed as the incubation time of LDL oxidation reaction of P2, P11 and P12 were 210 min, 102 min and 100 min respectively (P0.05), compared with BHT (130 min) and control (75 min). The pomelo flavonoids extracts can decrease TG, TC and LDL-C level but increase HDL-C level in mice with high blood lipids induced by egg yolk (P0.05). Conclusion: The flavonoids antioxidants in pomelo peel can inhibit human LDL oxidation and improve lipid profile in mice with high blood lipids. The major antioxidative component of the flavonoids in pomelo peel is P2 (eriocitrin).
【Fund】: 广东省自然科学基金项目(NO.990891)
【CateGory Index】: R285
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