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《Acta Nutrimenta Sinica》 2006-01
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STUDY ON THE ANTIOXIDANT ACTIVITY OF SWEET POTATO ANTHOCYANIN AND ITS INHIBITING EFFECT ON GROWTH OF CANCER S_(180)

WANG Guan-lin, YUE Jing , SU Dong-xia, FANG Hong-jun (College of Life Science, Liaoning Normal University, Dalian 116029,China)  
Objective: To study the antixiodant activity of sweet-potato anthocyanin (SPAC) and its inhibiting effect on growth of cancer S180. Method: The scavenging capacity of ??O2 and·OH and the inhibitory effect of MDA were determined in vitro.The SOD activity of serum and skin, the effect on S180 growth, serum GSH-Px activity and MDA were tested in mice. Results: SPAC had antioxidant activity in vitro, with elimination rate of O2?? and·OH 30.63% and 20.57% higher than the same concerntration of VC respectively. Activity of SOD in the serum and skin of mice were raised 27.30% and 13.50% respectively after giving SPAC. The growth rate of cancer S180 in the mice was inhibited, and the highest inhibitory rate was 43.12%. The activity of serum GSH-Px, SOD of the mice was raised as compared to control, but MDA declined . Conclusion: SPAC is a perfect natural pigment with inhibitory effect on growth of cancer S180 probably through its antioxidant activity.
【Fund】: 辽宁省政府科技攻关项目(No.97064)
【CateGory Index】: R151
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