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《Acta Nutrimenta Sinica》 2008-06
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STUDY ON THE EFFECT OF LIPOIC ACID ON SCAVENGING FREE RADICALS PRODUCED IN THE DIGESTIVE SYSTEM OF MICE FED HIGH-FAT DIET

WANG Yan-yan2 , SHI Yong-hui 1, 2, YIN Cai-na2, WANG Shu-ping2, WANG Zhou-ping1, 2,LE Guo-wei1, 2 (1The State Key Laboratory of Food Science and Technology,Jiangnan University, Wuxi 214122; 2 Jiangnan University, School of Food Science and Technology, The Institution of Food Nutrition and Safety,Wuxi 214122, China)  
Objective To explore the scavenging effect of lipoic acid (LA) on free radicals produced in the digestive system of high-fat fed mice. Method Mice were randomly assigned to four groups. The control group consumed ordinary diet,The other three groups were fed with high-fat diet, high-fat diet plus 0.05% or 0.1% LA. After 6 w, the free radicals and anti-oxidation indices of whole blood and gastrointestinal system were examined. Results As compared with control group, the levels of free radicals in blood, stomach, pancreas, duodenum,jejunum and ileum were significantly increased and the anti-oxidation indices significantly decreased in high-fat diet group, and all of them recovered nearly to the control when 0.1% LA was added to the high-fat diet but no effect when 0.05% LA was added. Conclusion High-fat diet can significantly increase the levels of free radicals produced in digestive system and decrease the anti-oxidation capacity of mice. The optimal dose of LA can availably eliminate free radicals and increase the anti-oxidative capacity of mice fed high-fat.
【Fund】: 国家自然科学基金(No.30571347)
【CateGory Index】: R151
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