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《Acta Nutrimenta Sinica》 2012-01
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EFFECTS OF RESVERATROL SUPPLEMENTATION ON THE REPAIR OF EXERCISE-INDUCED SKELETAL MUSCLE MICRO-DAMAGE IN MICE

WEN Jian-fei1,2,SUN Gao-feng3,WANG Qiang2,LIU Yu-qian1,WANG Hai-tao1(1Department of Physical Education,Hebei Normal University,Shijiazhuang 050016;2 Hefei Noumal University,Hefe 230016;3Departmemt of Sports and Military Education,Anhui Univeraity 230039,China)  
Objective To investigate the effect of resveratrol supplementation on the repair of exercise-induced skeletal muscle micro-damage in mice and the possible mechanisms.Method Seventy male Kunming mice were randomly divided into three groups: control group(CG),exercise group(EG) and exercise + resveratrol group(ER).EG group and ER group were divided into three sub-groups by post-exercise 0 h,24 h,48 h,(n=10).ER group was given i.g.resveratrol with 10 mg/kg.d,and proceeded with treadmill training with EG group for 4-w,then continued 90 min of treadmill exercise at gradient 0 and speed 18 m/min.The myofibril and Z-line anomalies were observed by electron microscope,and serum creatinine kinase(CK),lactate dehydrogenase(LDH),muscle tissue superoxide dismutase(SOD) activities,malon-dialdchyde(MDA) content were measured.Results The electron microscopy showed that EG group appeared sarcomere disarray,Z-line streaming,and waveform changes,the injury level of ER group was less than that of EG group,and after 48h the injury in skeletal muscle was restored.Serum CK and LDH activities of ER group were significantly lower than those of EG group,especially after exercise 24h,48h(P0.05).SOD activity in skeletal muscle of ER group was significantly increased and MDA significantly decreased compared with EG group(P0.05).Conclusion Resveratrol could promote repair of exercised-induced skeletal muscle microdamage in mice and the mechanism was possibly relative to its powerful antioxidant capabilities,as scavenging free radicals,reducing lipid peroxidation,and maintaining muscle cell structure and function.
【Key Words】: resveratrol skeletal muscle exercise-induced skeletal muscle micro-injury
【Fund】: 河北省教育厅基金(No.Z2008119);; 河北师范大学青年基金(No.L2007Q20)
【CateGory Index】: R285.5;R87
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