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《ACTA NUTRIMENTA SINICA》 1994-01
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EFFECT OF Na2SeO3一SUPPLEMENTATION ON FLUORINE CONTENT,ANTI-OXIDATIVE ENZYMES ACTIVITIES AND LIPID PEROXIDATION OF THE PATIENTS WITH FLUOROSIS

Bian Jianchao; Xian Shumei; Ye Ping; Wang Xuesong; Liu Chuanjiao;Liu Yongping(Shandong Institute of Prevention and Treatment of Endemic Disease,Jinan 250014)  
The contents of selenium(Se)and fluorine(F)in serum, urine and hair,the activity of glutathione peroxidase(GSH一px) in erythrocyte, the activity and content of superoxide dismutase(SOD) in red blood cells,the activity of SOD in serum and the content of lipid peroxide(LPO) in serum of 40 pati一ents with dental fluorosis and 78 patients with skeletal fluorosis were deter一mined in an area with a high concentration of F in the drinking water and a low concentration of Se in the cnvironment before and after Na2SeO3-sup, plementation. The results showed that the level of Se in the serum,urine and hair of the patients of both groups was higher after Se-supplementation. At the same time, the content of F in urine increased and in serum decreased.Increases of the activities of GSH一px,SOD in RBC and of the rate of GSH一Px/LPO, SOD/LPO, decrease of the content of LPO in serum of the patients were observed,Se might be aNeto improve the function of anti一oxidative enzymes and lower the damage of LPO. Meanwhile it also had an antagonistic effect on high concentration of F in the patients with fluorosis in an area of low level of Se.
【Fund】: 山东省卫生厅科研经费
【CateGory Index】: R599.9
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