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EFFECT OF OF COMBINED SELENIUM AND GERMANIUM ON RAT LIVER LIPID PEROXIDATION INDUCED BY ALCOHOL

Yang Chengfeng;Chen Xuemin;Liu Jun;Zheng Wenxin;Chang Wei;Yang Kedi(Department of Environmental Health,Tongji Medical University,Wuhan 430030)  
he synergistic antioxidation of combinf3d selenium(Na_2SeO_3)and germa-nium(Carboxyethyl germanium sesquioxide,Ge-132)was studied in the mo-del of rat liver lipid peroxidation incuced by alcohol in vitro and in vivo.The results showed that alcohol could cause rat liver lipid peroxidation in vitro and in vivo,The combination of selenium and germanium(Na_2SeO_3,20μmol/L+Ge-132,10.5 mmol/L) had stronger antioxidation effect than that of the same dosage of selenium(Na_2SeO_3,20μmol/L)or germanium(Ge-132,10.5mmol/L)alone in vitro.In vivo study,the combination of half dosages of selenium and germanium(Na_2SeO_3,0.055 mg/kg + Ge-132,100 mg/kg)hadthe similar antioxidation effect as high dosage of selenium(Na_2SeO_3,0.11mg/kg)alone,and had stronger antioxidation effect than that in high dosa-ge of germanium(Ge-132,200mg/kg)alone.The results indicated that sele-nium(Na_2SeO_3)and germanium(Ge-132)had synergistic antioxidation invitro and in vivo.
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