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《ACTA NUTRIMENTA SINICA》 1998-01
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TX THE EXPERIMENTAL STUDY ON THE ANTITUMOR EFFECTS OF BETACAROTENE AND SODIUM SELENITE IN VITRO

Zhou Xinwen,Zhang Yueming,Zhen Yupei,Cui Qingping(Department of Preventive Medicine Xingjiang Medical College,Urumqi 830054)  
The effects of βcarotene and/or inorganic selenium(Na2SeO3)on human hepatic carcinoma cell line (Q3)and human bladder carcinoma cell line(T24)were studied with technique of cell culture.Fibroblast cell line of mouse served as normal control cell line.There were three parts in the test:1,Studying the effect of βcarotene with dose of 3,30,100 μ mol/L,dissolvent control being DMSO;2.Investigating the effect of sodium selenite (Na2SeO3)with dose of 0.3,3.0,10 μ mol/L,dissolvent control being saline;3.Examining the effect of the combination of βcarotene and sodium selenite,their concentrations being 1.5+0.15,15+15,50+5μ mol/L, dissolvent control being DMSO and saline.A blank control was arranged in each group.The survival rate and the protein content of the cultured cells were observed at 24h,48h and 72h.The results showed that:1.There was a significant growth inhibition on both of the two carcinoma cell lines by each dose group of βcarotene;2.The growth inhibition on cultured cells by inorganic selenium was weaker,but the inhibitory effect was significant by increasing dose and prolonging the cultured time.The growth inhibitory effect of βcarotene and sodium selenite was stronger on (Q3) line than (T24) line.The inhibitroy effects of the combination of βcarotene and sodium selenite on Q3 and T24 carcinoma cell lines indicated that there was additive effect between them.
【Fund】: 研究生经费
【CateGory Index】: R151.41
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