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《Journal of Yunyang Medical College》 2007-06
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Content determination of Metronidazole in Metronidazole Beclometasone Cream by High Performance Capillary Electrophoresis

WANG Xuan-bin,LIU Ying,LIU Ming,DAI Yuan-ying,ZHOU Xiao-yan,HUANG Kai-yun,TANG Bing,GENG Ji-qing(Department of Pharmacy,Renmin Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China)  
Objective To determine content of metronidazole(MTZ)in metronidazole beclometasone cream by high performance capillary electrophoresis(HPCE).Method Capillary zone electrophoresis(CZE) optimized previously was performed with electrokinetic injection time 20 seconds(10 kV) at the separation voltage of 24 kV,detection wave length 300nm,and column temperature 25℃ with 40mmol/L Tris-H3PO4 solution as running buffer.Results The retention time of MTZ by HPCE was 8.17min.The calibration curve was y=0.0394x+0.0078(r=0.9995) with the content range of 1.25~75.00 μg/mL.The internal day precision RSD was 1.35~2.01%(n=5) while the intraday precision RSD was 3.11~4.62%(n=5).The mean content of MTZ in MBC by HPCE was 97.30%.Conclusion HPCE may be potential method in the concentration determination of metronidazole,because of its minute sampling,rapidness,convenience and accuracy.
【CateGory Index】: R927
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