Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Hubei University of Medicine》 2010-06
Add to Favorite Get Latest Update

Effects of Penehyclidine Hydrochloride on Lung Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

YU Kai-feng,PAN Xue-lian,LI Ying-bo (Department of Anesthesiology,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)  
Objective To study the effects of penehyclidine hydrochloride on lung fuction in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB) and its possible mechanism.Methods Twenty-four cardiac surgical patients were randomly divided into control group(group C,n=12) and penehyclidine hydrochloride group(group P,n=12).Penehyclidine hydrochloride(0.02 mg/kg) was intravenously injected at 30 min before CPB in group P,meanwhile 5 mL physiological saline was injected in group C.The concentration of TNF-α and IL-6 in plasma was measured and blood gas analysis was performed at pre-CPB(T1),30 min after aorta opening(T2)and 4 h(T3) and 24 h(T4) after CPB,and the alveolar-arterial oxygen pressure difference[P(A-a)DO2] and respiratory index(RI)was measured with artery blood gas analysis.Results P(A-a)DO2,RI,TNF-α and IL-6 constrations in plasma in two groups at T2,T3 and T4 were significantly increased compared with those at T1(P0.05);the above-mentioned indexes at T2,T3 and T4 in group P were all significantly lower than those of group C(P0.05).Conclusion Penehyclidine hydrochloride could protect the lung function of patients undergoing cardiac surgery with CPB through inhibiting secretion of TNF-α and IL-6.
【CateGory Index】: R614.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 Wang Tao;Zhou Yeting;Zhu Anxiang;You Chuanping;Department of Anesthesiology,Shuyang People's Hospital;;Penehyclidine hydrochloride and organ protection during cardiopulmonary bypass[J];国际麻醉学与复苏杂志;2014-04
2 ZHENG Min1,TIAN Gang1,GU Jun-feng1,YANG Jian-ye2,QIU Gui-hua2,LEI Ling3(1Department of Anesthesiology,2Institute of Clinical Medicine,3Department of Ultrasound Diagnosis,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China);Effect of Ketamine on TNF-α and NF-κB of Lung in Rats Model of Hemorrhagic Shock and Protection of Ketamine on Lung[J];湖北医药学院学报;2012-03
3 LI Ying-bo,RAN Ran,PAN Xue-lian*(Department of Anesthesiology,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China);Influence of Different Dosage Propofol on Pulmonary Function in Patients with Cardiopulmonary Bypass[J];湖北医药学院学报;2011-06
【Citations】
Chinese Journal Full-text Database 7 Hits
1 WU Xiaojing,XIA Zhongyuan,WANG Lingli,LI NingtaoDept.of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Effects of Penehyclidine Hydrochloride on Traumatic Acute Lung Injury-Induced Proinflammatory Cytokine Production in Rats[J];武汉大学学报(医学版);2010-03
2 WANG Lei,LUAN Yong,ZHAO Fu-long(Department of Anesthesiology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China);Penehyclidine hydrochloride in cardiopulmonary bypass[J];大连医科大学学报;2010-02
3 AI Yanqiu1),XIE Xiaojuan2),ZHANG Wei1),GENG Hongfang1),LI Ning1)1)Department of Anesthesiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)Department of Anesthesiology,the First Affiliated Hospital,Henan University of Science and Technolgy,Luoyang 471003;Effect of penehyclidine hydrochloride on the levels of myocardium NF-κB and plasma TNF-α in patients undergoing heart valve replacement[J];郑州大学学报(医学版);2009-05
4 YUAN Huimin,YANG Weihong,ZHANG Jiangrong.Department of Geriatrics,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Serum levels of soluble Fas and inflammatory cytokines in elderly patients with coronary heart disease[J];中华实用诊断与治疗杂志;2008-12
5 WANG Feng;Protective Effect of Penehyclidine on Lung Injury in Infants Undergoing Cardiopulmonary Bypass[J];实用儿科临床杂志;2008-16
6 CUI Hujun 1△ , ZHANG Mingli 1, XIAO Feng 1, LI Yan 1,WANG Jin 1, CHEN Hongyi 2 (1. Department of Cardiac surgery, 2. Department of Thoracic surgery, Peking University First Hospital, Beijing 100034, China);Comparison and correlative analysis of pulmonary function markers after extracorporeal circulation[J];北京大学学报(医学版);2003-02
7 NIU Wen Zhong 1, GAO Zhan Guo, ZHAO De Lu, LIU Chuan Gui (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850; 1 Epidemic Prevention Team, Logistics Department of Chengdu Military Command, Chengdu 61;Binding profiles of 3 (2 hydroxy 2 cyclopentyl 2 phenyl ethoxy) quinuclidine and its optical isomers to peripheral muscarinic receptors[J];中国药理学与毒理学杂志;1999-01
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 SHAN Wenbin;LIU Kai;HU Jihong;JIN Limei;YI Kang;Gansu University of Traditional Chinese Medicine;Department of Cardiovascular Surgery,Gansu Provincial Hospital;;The protective effect of glucocorticoid on lung injury under cardiopulmonary bypass:A Meta-analysis[J];中国医药科学;2016-09
2 Xin-ping YANG;Jia-hua SHI;Han YANG;Jian-fang LU;Shao-nong HUANG;Department of Anesthesiology, the Second People's Hospital of Shenzhen;;Effects of Penehyclidine hydrochloride on blood pressure and heart rate variability of CHD patients in perianesthesia period[J];中国现代医学杂志;2015-32
3 Xin CAO;Ke-bing ZHOU;Department of Emergency Medicine, Nanhua Hospital, Nanhua University;;Effects of penehyclidine hydrochloride on plasma levels of SP-D, TNF-α and IL-8 in patients with acute lung injury induced by multiple trauma[J];中国现代医学杂志;2015-16
4 ZHANG Yongqiang;LU Wei;ZHENG Hong;WANG Jiang;Department of Anesthesiology,The First Affiliated Hospital of Xinjiang Medical University;;Influence of using same dose sevoflurane in different phase during valve replacement surgery on lung function[J];新疆医科大学学报;2014-08
5 Wang Yuanming;Yang Peng;Clinical Medicine Department,Fenyang College of Shanxi Medical University;Cardiovascular Medicine Department,Fenyang Hospital;;Effects and mechanism of penhyclidine hydrochloride on myocardial ischemia reperfusion injury in rat[J];中国综合临床;2014-08
6 HUANG Qian;ZHANG Bing-dong;WANG Ling;Department of Anesthesiology and Cardiovascular Institute,the First Affiliated Hospital of Guangxi Medical University;;The effects of right stellate ganglion block on rat microcirculation during extracorporeal circulation[J];中国临床新医学;2014-05
7 Zhen Su;Wei Cai;Department of Anesthesiology,Huai'an First People's Hospital,Nanjing Medical Unversity;Department of Orthopedics,Huai'an First People's Hospital,Nanjing Medical Unversity;;Protective effect of penehvclidine hydrochloride on ischemia— reperfusion injury in rats[J];Asian Pacific Journal of Tropical Medicine;2014-01
8 LI Jin-xiu;JIAO Xian-fa;ZHANG Ke;Intensive Care Unit,Zhengzhou People's Hospital;;An intervention study of penehyclidine hydrochloride for the treatment of respiratory insufficiency caused by acute hydrogen sulfide poisoning[J];中国急救医学;2013-11
9 You lu;Chen song;Wang yong;Li shanshan;Dou xuejiao;Zhang hong;Department of Anesthesiology,The Affiliated Hospital of Zunyi Medical University;;Establishment of dog lung ischemia-reperfusion injury of cardiopulmonary bypass model[J];遵义医学院学报;2013-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Shu Li-juan,Wei Xin-chuan Department of Anesthesia,West China Hospital,Sichuan University,Sichuan 610041,China;Effect of Penehyclidine hydrochloride in systemic inflammatory response syndrome caused by cardiopulmonary bypass[J];中国体外循环杂志;2012-01
2 PENG Hui-hua,JIANG Wei-hang,CHENG Ping-rui,HUANG Fang(Department of Anesthesiology,the Panyu Central Hospital of GuangZhou,Guangdong,511400,China);Protection of Penehyclidine Hydrochloride on the Gastrointestinal Mucosal Injury in Patients During Cardiopulmonary Bypass[J];湖北医药学院学报;2012-01
3 Ying-Jie Sun,Hui-Juan Cao,Qiang Jin,Yu-Gang Diao,TieZheng Zhang,Department of Anesthesiology,General Hospital of Shenyang Commend,Shenyang 110840,Liaoning Province,China;Effects of penehyclidine hydrochloride on rat intestinal barrier function during cardiopulmonary bypass[J];World Journal of Gastroenterology;2011-16
4 ZHOU Ai-guo,PAN Dao-bo,CHEN An-ji,et al(Department of Anesthesiology,First People's Hospital of Changde City,Hunan 415000,China);Effect of Penehyclidine Hydrochloride on Cerebral Oxygenation and Blood Lactic Acid in Patients Undergoing Valve Replacement Surgery with Cardiopulmonary Bypass[J];医学临床研究;2010-12
5 YU Kai-feng,PAN Xue-lian,LI Ying-bo (Department of Anesthesiology,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China);Effects of Penehyclidine Hydrochloride on Lung Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass[J];湖北医药学院学报;2010-06
6 YAN Bin,LI Yan-bing,ZENG Shao-bo,JIANG Bin (Department of Hepatobiliary Surgery,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China);Induction of NF-κB Decoy Oligonucleotides Combined with Adriamycin on the Apoptosis of Hepatoma Carcinoma HepG_2 Cells in Nude Mice[J];湖北医药学院学报;2010-05
7 LIU Liu,ZHOU Hai-yang,WANG Jian-bin,L Zhi-ping(Department of Anesthesiology,Xiangya Second Hospital,Central South University,Changsha 410011,China);Effect of penehyclidine on myocardial ischemia-reperfusion injury in patients undergoing valve replacement[J];中国新药杂志;2010-15
8 LI Xing-wang1,SHANG You2,ZHANG Bing1,HU Ming-pin1,LIAN Qing-quan11Department of Anesthesiology,Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,Zhejiang,China;2Department of Anesthesiology,Union Hospital,Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022,Hubei,China;Protective effect of triptolide against severe acute pancreatitis-associated lung injury in rats[J];中国临床药理学与治疗学;2009-01
9 YUAN Huimin,YANG Weihong,ZHANG Jiangrong.Department of Geriatrics,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Serum levels of soluble Fas and inflammatory cytokines in elderly patients with coronary heart disease[J];中华实用诊断与治疗杂志;2008-12
10 DONG Lan LI Shu-ren HAN Shu-jun,et al Department of Anesthesiology,General Hospital of Chinese People's Armed Police Forces,Beijing 100039,China;Effects of penequinine hydrochloride on interleukin-8 and nuclear factor-κB during orthotopic liver transplantation[J];临床麻醉学杂志;2008-09
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 OU Huo-lian;Department of Anesthesia,The Second People's Hospital of Zhuhai City;;The effect of penehyclidine hydrochloride on the bacterial translocation of the intestinal mucosa and the expression of plasma sIgA in infectious shock rats[J];临床和实验医学杂志;2017-24
2 Deng Yanna;Long Hongjie;Department of Anesthesiology,Huizhou Third People's Hospital;;Protection role of propofol on renal function in extracorporeal circulation operation[J];国际麻醉学与复苏杂志;2015-09
3 TU Qingmei;TIAN Gang;ZHENG Min;Department of Pharmacology,Taihe Hospital Affiliated to Hubei Medicine College;;Effects of Montelukast on MDA and GSH levels in pulmonary tissue of rats with hemorrhagic shock followed by resuscitation-induced acute lung injury[J];河北医药;2015-05
4 TIAN Gang;TU Qingmei;ZHENG Min;JIANG Zhenzhen;LUO Xingjun;ZHAO Xiang;Renmin Hospital Affiliated to Hubei University of Medicine;Taihe Hospital Affiliated to Hubei University of Medicine;;Effects of montelukast on serum TNF-α and IL-6 levels in rats with hemorrhagic shock followed by resuscitation induced acute lung injury and lung protective effect[J];现代中西医结合杂志;2015-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 FEI Aihua,LIN Jixian,LIU Xiaohong,et al.Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Experimental study on cardiomyocyte apoptosis by simvastatin after acute myocardial infarction in rat[J];实用诊断与治疗杂志;2008-06
2 SUN Lifang,CAO Guoliang.Department of Cardiology,Jinshan District Central Hospital,Shanghai 201500,China;Effect of early simvastatin therapy on IL-6 and nuclear factor κB activity in patients with acute myocardial infarction[J];实用诊断与治疗杂志;2008-04
3 TANG Shi-lin,YANG Hui,CHEN Hong-fang,et al(Department of Intensive Care Unit,the First Affiliated Hospital of Nanhua University,Hengyang,Hunan 421001,China);Therapeutic Effects of Penehyclidine Hydrochloride on the Respiratory Function of Patients With Acute Lung Injury[J];南华大学学报(医学版);2007-06
4 ZHANG Hai-ping,GUO Qu-lian.Department of Anesthesiology,Xiangya Hospital,Central South University,Changsha 410008, China;Effect of fructose-1,6-diphosphate on oxygen metabolism during cardiopulmonary bypass[J];临床麻醉学杂志;2007-08
5 PAN Yan-feng,ZHANG Gui-xin,LIU Chao(Department of Neonatology,the First People's Hospital of Zhumadian City,Zhumadian 463000,China);Curosurf for treatment of thirty neonates with acute lung injury[J];新乡医学院学报;2007-03
6 HE Yun-yan,HE De-pei,LUO Yun-li,et al.(Department of Clinical Laboratory,Chongqing Zhongshan Hospital,Chongqing Cardiovasalar-Thoracic Diseases Research Center,Chongqing 40013,China);Research of protecting cardiac muscle pretreated with penehyclidine hydrochloride during open heart surgery with cardiopulmonary CPB[J];重庆医学;2007-07
7 LI Da-zhen,YE Mao,XU Ying(Department of Anesthesia,Children′s Hospital Affiliated to Chongqing University of Medical Sciences,Chongqing 400014,China);Protective Effect of Shenfu Injection on Circulation Function in Infants Undergoing Cardio-Pulmonary Bypass[J];实用儿科临床杂志;2007-07
8 LI Jing-wen1,LONG Cun1,Yuan Quan2,GAO Guo-dong1(1.Department of Cardiopulmonary Bypass,Cardiovascular Institute and Fu Wai Hospital,CAMSand PUMC,Beijing 100037;2.Department of surgery Zhenlai Central hospital of Jilin Province,Jilin Zhenlai,137300,China);Changes of Lactic Acid and Prognosis of Diseases During Cardiac Surgery in Infants[J];中国体外循环杂志;2007-01
9 Lu Guangkui, Qin Zhigang, Huang Weiqin,et al. Department of Anesthesiology, Wuhan Asia Heart Hospital, Wuhan 430022 CHINA;Clinical application of penehyclidine hydrechloride as premedication in children undergoing cardiac surgery[J];临床麻醉学杂志;2006-11
10 YANG Jieying.Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Effect of fructose 1,6-diphosphate therapy on inflammatory factors in acute coronary syndrome[J];实用诊断与治疗杂志;2006-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved