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《Journal of Hubei University of Medicine》 2010-06
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Effects of Penehyclidine Hydrochloride on Lung Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

YU Kai-feng,PAN Xue-lian,LI Ying-bo (Department of Anesthesiology,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)  
Objective To study the effects of penehyclidine hydrochloride on lung fuction in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB) and its possible mechanism.Methods Twenty-four cardiac surgical patients were randomly divided into control group(group C,n=12) and penehyclidine hydrochloride group(group P,n=12).Penehyclidine hydrochloride(0.02 mg/kg) was intravenously injected at 30 min before CPB in group P,meanwhile 5 mL physiological saline was injected in group C.The concentration of TNF-α and IL-6 in plasma was measured and blood gas analysis was performed at pre-CPB(T1),30 min after aorta opening(T2)and 4 h(T3) and 24 h(T4) after CPB,and the alveolar-arterial oxygen pressure difference[P(A-a)DO2] and respiratory index(RI)was measured with artery blood gas analysis.Results P(A-a)DO2,RI,TNF-α and IL-6 constrations in plasma in two groups at T2,T3 and T4 were significantly increased compared with those at T1(P0.05);the above-mentioned indexes at T2,T3 and T4 in group P were all significantly lower than those of group C(P0.05).Conclusion Penehyclidine hydrochloride could protect the lung function of patients undergoing cardiac surgery with CPB through inhibiting secretion of TNF-α and IL-6.
【CateGory Index】: R614.4
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