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Effect of Valeriana Officinalis Var Latifolia Miq on blood Lipid Metabolism in Experimental Hyperlipidemic Rabbits

Hu Changxing 1,Yang Guiyuan 1,Li Gengshang 2 ( 1 Department of Cardiology,the Affiliiated Hospital,Yunyang Medical College,Shiyan 442000 2 Department of Cardiology the First Affiliated Hospital Hubei Medical University)  
Objective:To evaluate the effects of valeriana officinalis varlatifolia miq(VOL) oil on the blood lipid metabolism in experimental hyperlipidemic rabbits.Methods:Injured by immunoreaction and fed with 1.5% cholesterol diet for 45 days,the 32 male rabbits were randomly divided into four groups(8 in each): atherosclerosis control group (CAS, fed with common diet),low-dose VOL group(VOL 1, common diet + VOL oil 150 mg/day). High-dose VOL group (VOL 2,common diet + VOL oil 500 mg/day), simvastatin group (ST, common diet + ST 5mg/day).The experiment lasted 105 days.Blood samples were collected before the experiment and 45 days, 75 days and 105 days after the experiment from all the rabbits for measurement of serum total cholesterol (TC),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG), high-density lipoprotein cholesterol(HDL-C) respectively.Results:TC,TG and LDL-C were significantly lowered in VOL 2 and ST groups(P0.01,P0.05),compared with CA group.Serum lipid had no significant differences in VOL 1 group,compared with ST group(P0.05).Conclusion:VOL oil plays a significant role in the modification of lipid.
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