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《JOURNAL OF YANGZHOU UNIVENSITY NATARAL SCIENCE EDITION》 1999-01
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REGRESSION METHOD FOR MAPPING QUANTITATIVE TRAIT LOCI WITH MEANS OF FLANKING MARKER GENOTYPES

Xu Chenwu Gu Shiliang (Dept of Agron, Agric Coll, Yangzhou Univ, Yangzhou, 225009)  
A simple statistical method for mapping quantitative trait loci regression with means of flanking marker genotypes was proposed in this paper. Which used the quantitative trait means of flanking marker genotypes as dependent variable Y, the coefficient of additive and dominance effect of putative QTL in a interval as independent variable X 1 and X 2 . Like Lander and Botstein′s interval mapping, this method can be performed at any position in a genome covered by markers. The effect and location of QTL can be estimated simutaneusly. For increasing the estimation precision of QTL location, the interference of other relative QTL was controlled statistically as Zeng′s composite interval mapping when scanning QTL in a interval. The analyzing procedure was demonstrated with Zheng′s data of rice fertile rate and the difference between this method and interval mapping was compared directly. The result showed the feasibility of this method for mapping QTL.
【Fund】: 农业部“九五”生物技术研究项目
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